Objective

To quantify photophobia in visual snow syndrome (VSS), a debilitating migraine-associated visual disturbance manifesting with continuous “TV snow-like” flickering dots in the entire visual field and additional visual symptoms, such as photophobia.

Methods

Photophobia was compared between 19 patients with VSS and 19 controls matched for age, sex, migraine and aura using the Leiden Visual Sensitivity Scale (L-VISS).

Results

Patients with VSS had an increased L-VISS-score compared to matched controls [(22.2 ± 5.9 vs. 4.4 ± 4.8; ANOVA, factors VSS and comorbid migraine: Main effect for VSS (F = 100.70; p < 0.001), but not for migraine (F < 0.01; p = 1.00) or the interaction (F = 1.93; p = 0.16)]. An L-VISS-score of 14 identified VSS with a sensitivity and specificity of 95% (Receiver Operating Characteristic analysis, 0.986 ± 0.014, p ≤ 0.001).

Conclusion

Patients with VSS suffer continuously from photophobia at a level similar to chronic migraineurs during attacks. Although migraine and VSS share dysfunctional visual processing, patients with VSS might be more severely affected.

中文翻译：

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视雪综合征中畏光的量化：一项病例对照研究。

目的

为了量化视觉雪综合征（VSS）中的畏光，一种与衰弱相关的偏头痛相关的视觉障碍，表现为在整个视野中出现连续的“ TV雪状”闪烁点和其他视觉症状，例如畏光。

方法

使用莱顿视觉敏感度量表（L-VISS），对19位VSS患者和19位年龄，性别，偏头痛和先兆相匹配的对照组的畏光进行了比较。

结果

与匹配的对照组相比，VSS患者的L-VISS评分增加[（22.2±5.9与4.4±4.8； ANOVA，VSS因素和偏头痛合并症：VSS的主要作用（F = 100.70; p  <0.001），但无偏头痛（F <0.01; p  = 1.00）或相互作用（F = 1.93; p  = 0.16）]。L-VISS评分为14可鉴定VSS，敏感性和特异性为95％（受试者工作特征分析，0.986 ±0.014，p  ≤0.001）。

结论

VSS患者持续发作恐惧症，其水平与发作期间的慢性偏头痛相似。尽管偏头痛和VSS共享视觉功能障碍，但VSS患者可能受到的影响更大。