Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14,Neuropathology and Applied Neurobiology

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Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14
Neuropathology and Applied Neurobiology ( IF 5 ) Pub Date : 2020-02-05 , DOI: 10.1111/nan.12590
M Y Deng _{1,

2} , M Sill _{1,

3} , D Sturm _{1,

2,

4} , D Stichel _{5,

6} , H Witt _{1,

3,

4} , J Ecker _{1,

4,

7} , A Wittmann _{1,

2} , J Schittenhelm ₈ , M Ebinger ₉ , M U Schuhmann ₁₀ , D Figarella-Branger ₁₁ , E Aronica ₁₂ , O Staszewski ₁₃ , M Preusser ₁₄ , C Haberler ₁₅ , M Lauten ₁₆ , U Schüller ₁₇ , C Hartmann ₁₈ , M Snuderl ₁₉ , C Dunham ₂₀ , N Jabado _{21,

22} , P Wesseling _{23,

24} , M Deckert ₂₅ , K Keyvani ₂₆ , N Gottardo _{27,

28,

29} , F Giangaspero _{30,

31} , K von Hoff ₃₂ , D W Ellison ₃₃ , T Pietsch ₃₄ , C Herold-Mende ₃₅ , T Milde _{1,

4,

7} , O Witt _{1,

4,

7} , M Kool _{1,

3} , A Korshunov _{5,

6} , W Wick _{36,

37} , A von Deimling _{5,

6} , S M Pfister _{1,

3,

4} , D T W Jones _{1,

2} , F Sahm _{1,

5,

6}

Affiliation

Hopp Children's Cancer Center Heidelberg (KiTZ), University Hospital Heidelberg, Heidelberg, Germany.
Junior Research Group Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Center (KiTZ), University Hospital Heidelberg, Heidelberg, Germany.
Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Department of Neuropathology, Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital of Tübingen, Tübingen, Germany.
Department of Pediatric Hematology/Oncology, Children's University Hospital, Tübingen, Germany.
Department of Neurosurgery, Division of Pediatric Neurosurgery, University Hospital Tübingen, Tübingen, Germany.
Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix Marseille Univ, APHM, CNRS, INP, Marseille, France.
Department of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Clinical Division of Oncology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Institute of Neurology, Comprehensive Cancer Centre Vienna, Medical University of Vienna, Vienna, Austria.
Department of Paediatrics, Paediatric Haematology and Oncology, University of Lübeck, Lübeck, Germany.
Department of Paediatric Haematology and Oncology and Institute of Neuropathology, University Medical Centre Hamburg-Eppendorf, Research Institute at the Children's Cancer Centre Hamburg, Hamburg, Germany.
Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.
Department of Pathology, Division of Neuropathology, NYUSoM, New York, NY, USA.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Department of Human Genetics, McGill University, Montreal, QC, Canada.
Department of Pediatrics, McGill University, McGill University Heath Centre Research Institute, Montreal, QC, Canada.
Department of Pathology, Amsterdam Universities Medical Centers/VUmc, Brain Tumor Center Amsterdam University Medical Center, Amsterdam, The.
Princess Máxima Center for Pediatric Oncology, Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.
Institute of Neuropathology, University Hospital of Cologne, Cologne, Germany.
Institute of Neuropathology, University of Duisburg-Essen, Essen, Germany.
Telethon Kids Institute, Perth, WA, Australia.
Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.
Department of Oncology, Princess Margaret Hospital, Perth, WA, Australia.
Department of Radiological, Oncological and Anatomo-Pathological Science, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli (Is), Italy.
Department of Paediatric Haematology and Oncology, Charité-Universitätsmedizin, Berlin, Germany.
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Institute of Neuropathology, Brain Tumor Reference Center of the Society for Neuropathology and Neuroanatomy, University of Bonn Medical Center, Bonn, Germany.
Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.

DNA methylation‐based central nervous system (CNS) tumour classification has identified numerous molecularly distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that were previously thought to represent homogeneous diseases. Our study aimed at characterizing a novel, molecularly defined variant of glioneuronal CNS tumour.

中文翻译：

具有少突胶质细胞瘤样特征和核簇 (DGONC) 的弥漫性胶质神经元肿瘤 - 一种分子定义的胶质神经元 CNS 肿瘤类别，显示复发性单体 14

基于 DNA 甲基化的中枢神经系统 (CNS) 肿瘤分类已经确定了许多分子上不同的肿瘤类型，以及以前被认为代表同种疾病的已知 CNS 肿瘤实体中的临床相关亚组。我们的研究旨在表征胶质神经元中枢神经系统肿瘤的一种新的、分子定义的变体。

更新日期：2020-02-05

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