Abstract

A chemical investigation on the 95% ethanol extract of the aerial part of Gelsemium elegans resulted in the isolation of three new gelsedine-type indole alkaloids, 14β-hydroxygelselenidine (1), 11-methoxygelseziridine (2), and 14β-hydroxygelsedethenine (3). Structural elucidation of all the compounds was accomplished by spectral methods such as 1 D and 2 D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against five human non-small-cell lung cancer cell lines. Consequently, alkaloid 3 exhibited cytotoxic activities for all tested tumor cell lines with IC₅₀ values from 8.3 to 9.8 μM.

摘要

上的地上部分的95％乙醇提取物的化学调查钩吻导致了三个新gelsedine型吲哚生物碱，隔离14 β -hydroxygelselenidine（1），11-methoxygelseziridine（2），和14 β -hydroxygelsedethenine（3）。所有化合物的结构解析均通过光谱方法完成，例如1 D和2 D NMR，IR，UV和HRESIMS。在体外测试了分离的化合物对五种人类非小细胞肺癌细胞系的细胞毒活性。因此，生物碱3对所有测试的具有IC _50的肿瘤细胞系均表现出细胞毒活性 值介于8.3至9.8μM之间。