Obesity is a health problem in many countries, and maintaining a perfect weight is challenging. Moringa oleifera leaf extract (ME) is rich in polyphenols with antioxidant and pharmaceutical potential. The present study investigated the potential protective effect of Moringa oleifera leaf extract against obesity induced from a high-fat diet (HFD), oxidative stress and disruption of metabolic hormones compared to simvastatin (SIM) or their combination. Rats fed a HFD for 6 weeks exhibited a significant increase in body weight and levels of serum glucose and lipid fractions, verifying an obesity state. There were also higher levels of insulin and leptin and lower gherlin in sera of HFD rats compared to the levels in control rats. Homeostasis model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and the atherogenic index were elevated, indicating the development of insulin resistance and dyslipidaemia in these rats. These changes were accompanied with a significant increase in oxidative stress, as indicated by elevated lipid peroxidation and protein oxidation with low levels of antioxidants in liver. The activities of liver function enzymes, including aspartate amino transferase, alanine amino transferase, alkaline phosphatase and gamma glutamyltransferase, were also significantly increased in serum. Concurrent treatment with 300 mg/kg ME for 6 weeks ameliorated the increase in body weight and improved the levels of glucose, lipid fractions and metabolic hormones, indicating the anti-obesity effect and amelioration of tissue insulin resistance potential of ME. ME treatment also normalized oxidative stress and antioxidants in liver and improved liver function enzymes, indicating the antioxidant potential of ME. The effects of ME were similar to SIM, and the combination of these agents was better than each agent alone. We propose that ME extract has anti-obesity and antioxidant potential and may be used as a lipid-lowering drug to control weight, obesity and its pathophysiological consequences.

中文翻译：

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辣木叶提取物改善了高脂饮食诱导的肥胖，氧化应激和代谢激素紊乱

肥胖是许多国家的健康问题，保持理想体重是一项挑战。辣木叶提取物（ME）富含多酚，具有抗氧化剂和药物开发潜力。本研究调查了辣木叶提取物与辛伐他汀（SIM）或它们的组合相比，对高脂饮食（HFD）诱发的肥胖，氧化应激和代谢激素破坏的潜在保护作用。喂了HFD 6周的大鼠表现出体重的显着增加以及血清葡萄糖和脂质组分的水平，证实了肥胖状态。与对照大鼠相比，HFD大鼠血清中的胰岛素和瘦素水平较高，而谷胱甘肽水平较低。胰岛素抵抗的稳态模型评估（HOMA-IR），定量胰岛素敏感性检查指数（QUICKI）和动脉粥样硬化指数升高，表明这些大鼠胰岛素抵抗和血脂异常的发展。这些变化伴随着氧化应激的显着增加，如肝脏脂质过氧化和蛋白质氧化水平升高以及抗氧化剂含量低所表明的。血清中的肝功能酶，包括天冬氨酸氨基转移酶，丙氨酸氨基转移酶，碱性磷酸酶和γ-谷氨酰胺基转移酶的活性也显着增加。300 mg / kg ME并发治疗6周可减轻体重增加，改善葡萄糖，脂质组分和代谢激素的水平，表明ME具有抗肥胖作用和改善组织胰岛素抵抗的潜力。ME治疗还使肝脏中的氧化应激和抗氧化剂正常化，并改善了肝功能酶，表明ME的抗氧化潜力。ME的作用与SIM相似，并且这些药物的组合要优于单独使用每种药物。我们建议ME提取物具有抗肥胖和抗氧化的潜力，可以用作降脂药物来控制体重，肥胖症及其病理生理后果。