Dithiocarbamates (DTC) are the most commonly used synthetic fungicides in the Prosecco District (PD) of Treviso. The DTC biomarker is urinary ethylenethiourea (u-ETU). The aims of this biomonitoring study are to describe the level of u-ETU in residents in PD and to identify the factors associated with DTC exposure. In 2012 (baseline), we randomly extracted data for 126 children (3–5 years) and their families (260 adults), who were resident in 8 municipalities of PD and not occupationally exposed to DTC, from the local health database. For each subject, we obtained urine samples and socio-demographic, lifestyle and dietary information. In 2014 (after intervention), we evaluated the possible changes in u-ETU in 54 adults and 55 children at high risk of DTC exposure. The median baseline u-ETU was 0.35 µg/L. Approximately 5% of the samples had a u-ETU concentration > 5 µg/L. No u-ETU concentration exceeded 21 µg/L. Determinants of a higher u-ETU concentration were wine consumption (OR 2.04) and personal use of pesticides (OR 2.70) for adults; and living within 30 m from a vineyard (OR 9.51) and the pesticides use in the family (OR 6.25) for children. A significant u-ETU reduction in 49 adults and 25 children was observed from baseline to after intervention (p = 0.01). Wine consumption and production and DTC use in gardening influenced u-ETU concentrations in this population, although the levels were relatively low. The reduction in u-ETU from baseline to time after intervention probably reflects the effects of public health interventions.

中文翻译：

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葡萄园附近人口中的乙撑硫脲（u-ETU）水平

二硫代氨基甲酸酯（DTC）是特雷维索普罗塞科地区（PD）最常用的合成杀菌剂。DTC生物标志物是尿亚乙基硫脲（u-ETU）。这项生物监测研究的目的是描述PD居民中u-ETU的水平，并确定与DTC暴露相关的因素。在2012年（基准）中，我们从当地卫生数据库中随机抽取了126名3至5岁的儿童及其家人（260名成人）的数据，这些儿童居住在PD的8个直辖市中，没有职业性接触DTC的情况。对于每个受试者，我们获得了尿液样本以及社会人口统计学，生活方式和饮食信息。2014年（干预后），我们评估了54名成年人和55名DTC暴露高风险儿童的u-ETU可能发生的变化。基线u-ETU中位数为0.35 µg / L。大约5％的样品的u-ETU浓度> 5 µg / L。u-ETU浓度不超过21 µg / L。u-ETU浓度较高的决定因素是成年人的葡萄酒消费量（OR 2.04）和个人使用农药（OR 2.70）。距葡萄园30米以内（OR 9.51），而家庭中使用的农药（OR 6.25）则适用于儿童。从基线到干预后，观察到49名成人和25名儿童的u-ETU显着降低（p  = 0.01）。尽管该水平相对较低，但葡萄酒的消费和生产以及园艺中使用的DTC影响了该人群中u-ETU的浓度。干预后u-ETU从基线到时间的降低可能反映了公共卫生干预的效果。