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Regulation of bone morphogenetic protein 4 on epithelial tissue.
Journal of Cell Communication and Signaling ( IF 4.1 ) Pub Date : 2020-01-07 , DOI: 10.1007/s12079-019-00537-3
Sitong Shen 1 , Shurong Wang 1 , Yuxi He 1 , Huicong Hu 1 , Boyuan Yao 1 , Yan Zhang 1
Affiliation  

Epithelial tissues provide tissue barriers and specialize in organs and glands. When epithelial homeostasis is physiologically or pathologically stimulated, epithelial cells produce mesenchymal cells through the epithelial-mesenchymal transition, forming new tissues, promoting the cure of diseases or leading to illness. A variety of cytokines are involved in the regulation of epithelial cell differentiation. Bone morphogenetic proteins (BMPs), especially the bone morphogenetic protein 4 (BMP4) has a variety of biological functions and plays a prominent role in the regulation of epithelial cell differentiation. BMP4 is an important regulatory factor of a series of life activities in vertebrates, which is also related to cell proliferation, differentiation and mobility, it also has relation with tumor development. This paper mainly reviews the mechanism of BMP4’s regulation on epithelial tissues, as well as its effect on the growth, differentiation, benign lesions and malignant lesions of epithelial tissues, and expounds the function of BMP4 in epithelial tissues, to provide theoretical support for the research on reducing epithelial diseases.



中文翻译:

骨形态发生蛋白4在上皮组织中的调节。

上皮组织提供组织屏障,并专门用于器官和腺体。当生理上或病理上刺激上皮稳态时,上皮细胞通过上皮-间质转化产生间充质细胞,形成新组织,促进疾病的治愈或导致疾病。多种细胞因子参与上皮细胞分化的调节。骨形态发生蛋白(BMP),尤其是骨形态发生蛋白4(BMP4)具有多种生物学功能,并且在上皮细胞分化的调节中起着重要作用。BMP4是脊椎动物一系列生命活动的重要调控因子,也与细胞的增殖,分化和迁移有关,也与肿瘤的发展有关。

更新日期:2020-01-07
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