A case of fungal keratitis due to Coprinellus radians is reported. To our knowledge, fungal keratitis caused by this species was rare. Fungal hyphae were detected in corneal scrapings, and isolates were identified by morphology and by sequencing the internal transcribed spacer region of ribosomal DNA. The patient was treated with systemic and local antifungal therapy for 5 days, and lamellar keratoplasty was performed after no obvious improvement in symptoms. The in vitro antifungal susceptibilities of the case strain were tested for six antifungal agents. The results showed that 5-fluorouracil was resistant, fluconazole was moderately sensitive, and the other drugs assayed (amphotericin B, posaconazole, itraconazole and voriconazole) were highly effective against this fungus.

中文翻译：

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由弧形鬼伞引起的罕见真菌性角膜炎

报告了一例由弧形鬼伞引起的真菌性角膜炎。据我们所知，由该物种引起的真菌性角膜炎很少见。在角膜刮屑中检测到真菌菌丝，并通过形态学和对核糖体 DNA 的内部转录间隔区进行测序来鉴定分离物。患者全身及局部抗真菌治疗5天，症状无明显改善后行板层角膜移植术。对 6 种抗真菌剂测试了病例菌株的体外抗真菌敏感性。结果表明，5-氟尿嘧啶耐药，氟康唑中等敏感，其他检测药物（两性霉素B、泊沙康唑、伊曲康唑和伏立康唑）对这种真菌非常有效。