In Korean folk medicine, Artemisia iwayomogi has largely been employed for the improvement of diabetic complications and hepatic function as well as in the treatment of female diseases and skin whitening. Accordingly, the present study sought to assess cosmeceutical activity of Artemisia iwayomogi. Through activity-guided fractionation, scopolin (AI-1), 2,4-dihydroxy-6-methoxy-acetophenone 4-O-β-D-glucoside (AI-2), scopoletin (AI-3), kaempferol-3-O-methyl ether (AI-4) and luteolin (AI-5) were isolated from ethyl acetate and water fractions of Artemisia iwayomogi. Of them, AI-4 and AI-5 exhibited strong antioxidative and whitening effects. In addition, AI-1, AI-3, AI-4, and AI-5 demonstrated considerable anti-wrinkle performances. According to results of quantitative analysis of compounds isolated from Artemisia iwayomogi, scopolin (AI-1) is a major component of Artemisia iwayomogi. Moreover, O/W type cream made by water fraction which included scopolin showed unwrinkling effect for 8 weeks when it was applied to face in an in vivo study. Specific contributions of Artemisia iwayomogi were as follows: AI-1, 1.21 mg/g; AI-2, 0.26 mg/g; AI-3, 0.38 mg/g; AI-4, 0.01 mg/g; and AI-5, 0.04 mg/g.

中文翻译：

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从艾蒿中分离的化合物的体外和体内抗衰老作用

在韩国民间医学中，艾蒿主要用于改善糖尿病并发症和肝功能，以及治疗女性疾病和美白皮肤。因此，本研究试图评估 Artemisia iwayomogi 的药妆活性。通过活性引导分馏，东莨菪碱 (AI-1)、2,4-二羟基-6-甲氧基-苯乙酮 4-O-β-D-葡萄糖苷 (AI-2)、东莨菪碱 (AI-3)、山奈酚-3- O-甲基醚 (AI-4) 和木犀草素 (AI-5) 从艾蒿的乙酸乙酯和水馏分中分离出来。其中，AI-4和AI-5表现出很强的抗氧化和美白作用。此外，AI-1、AI-3、AI-4、AI-5表现出可观的抗皱性能。根据从艾蒿中分离出的化合物的定量分析结果，sccopolin (AI-1) 是 Artemisia iwayomogi 的主要成分。此外，在体内研究中，由含有东莨菪碱的水部分制成的 O/W 型面霜在涂抹于面部时显示出 8 周的去皱效果。Artemisia iwayomogi 的具体贡献如下：AI-1，1.21 mg/g；AI-2，0.26毫克/克；AI-3，0.38毫克/克；AI-4，0.01毫克/克；和 AI-5，0.04 毫克/克。