Abstract

Carbon nanotubes are newer generation material broadly emerged for biomedical applications due to its tempting properties such as size and aspect ratio covering surface area to the length, electrical, mechanical and thermal properties in addition to their unique architecture. The view for CNT-based nanomedicines is attractive and promising. Carbon nanotubes compared to other nanocarriers can be easily modified for conjugation of bioactive compounds and ligands for targeting. The applications of carbon nanotubes are not only limited to drug delivery but also in diagnostic applications. Due to a variety of applications in drug delivery, it is necessary to bear in mind the toxicities of carbon nanotubes and catch the way to overcome the problems related to toxicities. Currently, many studies have explored the biodegradation mechanism of carbon nanotubes. Biodegradation shows a conspicuous pathway that enables degradation and removal of CNTs from living body and catalyzes the release of the load from the CNTs. Many articles have been published till date which evidentiary provides the promising applications of CNTs. The present review seeks to provide an overview on intracellular fate, applications and toxicities of CNTs.

摘要

碳纳米管是新一代材料，广泛用于生物医学应用，因为除了其独特的结构外，它还具有诱人的特性，例如尺寸和纵横比，覆盖表面积到长度、电学、机械和热学特性。基于 CNT 的纳米药物的观点具有吸引力和前景。与其他纳米载体相比，碳纳米管可以很容易地进行修饰，以结合生物活性化合物和用于靶向的配体。碳纳米管的应用不仅限于药物输送，还包括诊断应用。由于在药物输送中的各种应用，有必要牢记碳纳米管的毒性，并找到克服与毒性有关的问题的方法。目前，许多研究探索了碳纳米管的生物降解机制。生物降解显示了一条显着的途径，该途径能够从活体中降解和去除 CNT，并催化负载从 CNT 中释放。迄今为止，已经发表了许多文章，这些文章为碳纳米管的有希望的应用提供了证据。本综述旨在概述碳纳米管的细胞内命运、应用和毒性。