By employment of the flexible bis-(imidazole-4,5-dicarboxylate) ligand (H₄L) ligand, a new luminescent Eu(III)-containing coordination polymer {[Eu(HL)(H₂O)₂]·2(H₂O)}_n has been successfully synthesized under hydrothermal condition by reaction of Eu(NO₃)₃·6H₂O with H₄L with the presence of NaOH as the pH modulator. The chemical composing of the as-prepared complex 1 has been determined via the elemental analysis and the structural arrangement was probed via the single crystal X-ray diffraction. Furthermore, complex 1 could also be applied as a luminescent sensor for the detection of p-nitroaniline, which has high sensitivity and selectivity. In biological research, the related anti-colon cancer activity on SW480 cancer cells was further evaluated. Firstly, the effect of compound on TRIB3 gene expression was evaluated by RT-PCR. The CCK-8 and transwell assay were next be performed to detect the inhibitory function of compound on SW480 cancer cell proliferation and migration. Finally, the results obtained through molecular docking simulation shed light on the understanding of Eu(II) metallic complex on DNA.

中文翻译：

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发光的Eu（III）配位聚合物：对硝基苯胺的选择性检测和通过抑制TRIB3介导的细胞增殖和迁移对结肠癌的治疗作用

通过使用灵活的双-（咪唑-4,5-二羧酸酯）配体（H ₄ L）配体，新的含发光Eu（III）的配位聚合物{[Eu（HL）（H ₂ O）₂ ]·2 （H ₂ O）} _n已在水热条件下通过Eu（NO ₃）₃ ·6H ₂ O与H ₄ L在NaOH作为pH调节剂的存在下反应成功合成。通过元素分析确定了所制备的配合物1的化学组成，并通过单晶X射线衍射探测了结构排列。此外，复数1也可作为发光传感器用于对硝基苯胺的检测，具有很高的灵敏度和选择性。在生物学研究中，进一步评估了对SW480癌细胞的相关抗结肠癌活性。首先，通过RT-PCR评估化合物对TRIB3基因表达的影响。接下来进行CCK-8和transwell测定以检测化合物对SW480癌细胞增殖和迁移的抑制功能。最后，通过分子对接模拟获得的结果阐明了对DNA上Eu（II）金属配合物的理解。