当前位置: X-MOL 学术J. Environ. Sci. Health B › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Assessment of DNA damage and cholinesterase activity in soybean farmers in southern Brazil: High versus low pesticide exposure.
Journal of Environmental Science and Health, Part B ( IF 2 ) Pub Date : 2019-12-23 , DOI: 10.1080/03601234.2019.1704608
Tanandra Bernieri 1 , Melina Floriano Moraes 1 , Patrícia Grolli Ardenghi 1 , Luciano Basso da Silva 1
Affiliation  

The aim of this study was to evaluate the DNA damage in soybean growers during two agricultural periods of a crop season (high and low exposure) and a control group, as well as butyrylcholinesterase (BChE) activity during these exposure periods in order to estimate the degree of BChE inhibition for the exposed group. DNA damage in peripheral whole blood was evaluated by the comet assay and plasma BChE activity was accessed as a measure of exposure to cholinesterase inhibitors. None of the soybean growers reported using full Personal Protective Equipment (PPE). BChE was lower in high exposure period than in low exposure period and DNA damage index was significantly increased in the high exposure period than in the low exposure period. In addition, DNA damage in both exposure periods was higher than control group. No correlation was found between exposure time and DNA damage and BChE activity. However, negative correlation was observed between DNA damage in high and low exposure periods. The results indicate that soybean growers are exposed to cholinesterase inhibitors and to pesticides mixtures with genotoxic potential.

中文翻译:

巴西南部大豆农民的DNA损伤和胆碱酯酶活性评估:农药暴露高低。

这项研究的目的是评估一个农作物季节的两个农业时期(高和低暴露水平)和一个对照组中大豆种植者的DNA损伤,以及在这些暴露期间的丁酰胆碱酯酶(BChE)活性,以评估暴露组的BChE抑制程度。通过彗星测定法评估外周全血中的DNA损伤,并获取血浆BChE活性作为接触胆碱酯酶抑制剂的量度。没有一个大豆种植者报告使用完整的个人防护设备(PPE)。高暴露期的BChE低于低暴露期的BChE,高暴露期的DNA损伤指数显着高于低暴露期。另外,两个暴露时期的DNA损伤均高于对照组。在暴露时间与DNA损伤和BChE活性之间未发现相关性。但是,在高和低暴露时间段的DNA损伤之间观察到负相关。结果表明,大豆种植者暴露于胆碱酯酶抑制剂和具有遗传毒性潜力的农药混合物中。
更新日期:2020-04-18
down
wechat
bug