Quercetin, a plant‐derived flavonoid, is known for its antitumor and antiproliferative activities. Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor prognosis that is approximately 12 months despite standard therapy. Therefore, because of the low effectiveness of the current therapeutic strategies, additional medications in combination with chemotherapy and radiotherapy are needed, which could improve the prognosis of GBM patients. Multiple lines of evidence have shown that quercetin regulates many proteins involved in the cellular signal transduction in GBM. In this review, recent findings on the targeting of particular signaling pathways by quercetin and the subsequent effect on the pathogenesis of GBM are presented and discussed.

中文翻译：

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槲皮素：一种有望治疗多形性胶质母细胞瘤的植物化学物质。

槲皮素是植物来源的类黄酮，以其抗肿瘤和抗增殖活性而闻名。尽管有标准疗法，多形胶质母细胞瘤（GBM）作为一种高度侵袭性的大脑肿瘤，预后较差，约为12个月。因此，由于当前治疗策略的有效性低，需要结合化学疗法和放射疗法的其他药物，这可以改善GBM患者的预后。多条证据表明槲皮素调节GBM细胞信号转导中涉及的许多蛋白质。在这篇综述中，提出并讨论了槲皮素靶向特定信号通路的最新发现以及对GBM发病机理的后续影响。