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Acoustic Energy Controlled Nanoparticle Aggregation for Nanotherapy.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control ( IF 3.6 ) Pub Date : 2019-11-26 , DOI: 10.1109/tuffc.2019.2956043
Hanmin Peng , Linli Mao , Xuejun Qian , Xiaolong Lu , Laiming Jiang , Yizhe Sun , Qifa Zhou

Patients with unresectable or nonablatable tumors are difficult to cure, but nanotherapy combining targeted nanoparticles has many severe side effects due to the toxicities of anticancer drugs. We found that acoustic energy can produce a local region with high concentration from a low concentration suspended liquid of nano-SiO 2 particles at 2.5 MHz. Our calculated results show that the main reason for aggregation is the synthesized effect of the potential well of acoustic energy and streaming to trap them. In addition, the aggregated region can be manipulated to a targeted position in the vessel phantom by moving the ultrasound transducer external to the body. This noninvasive manipulation of suspended nanoparticles can rapidly increase the local drug concentration, but reduce the total dosage of anticancer drugs, which has the potential to be used for patients with advanced tumors by improving the physiological effects and reducing the side effects.

中文翻译:

用于纳米治疗的声能控制纳米粒子聚集。

无法切除或不可切除的肿瘤患者很难治愈,但由于抗癌药的毒性,结合靶向纳米粒子的纳米疗法具有许多严重的副作用。我们发现声能可以从低浓度的纳米SiO 2悬浮液中产生高浓度的局部区域 2.5 MHz时的粒子。我们的计算结果表明,聚集的主要原因是声能势阱和流将其捕获的综合作用。另外,可以通过将超声换能器移动到体外来将聚集区域操纵到血管模型中的目标位置。悬浮纳米粒子的这种非侵入性操作可以迅速提高局部药物浓度,但会降低抗癌药物的总剂量,通过改善生理作用和减少副作用,这种药物有可能用于晚期肿瘤患者。
更新日期:2020-04-22
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