The innate immune response is crucial for defense against virus infections where the complement system, coagulation cascade and natural antibodies play key roles. These immune components are interconnected in an intricate network and are tightly regulated to maintain homeostasis and avoid uncontrolled immune responses. Many viruses in turn have evolved to modulate these interactions through various strategies to evade innate immune activation. This review summarizes the current understanding on viral strategies to inhibit the activation of complement and coagulation cascades, evade natural antibody-mediated clearance and utilize complement regulatory mechanisms to their advantage.

中文翻译：

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病毒与体液固有免疫反应的相互作用。

在补体系统，凝血级联和天然抗体起关键作用的情况下，先天免疫应答对于防御病毒感染至关重要。这些免疫成分在复杂的网络中相互连接，并受到严格调节，以保持体内平衡并避免不受控制的免疫反应。反过来，许多病毒已经进化为通过各种策略逃避先天免疫激活来调节这些相互作用。这篇综述总结了目前对病毒策略的认识，以抑制补体和凝血级联的激活，逃避天然抗体介导的清除，并利用补体调节机制发挥其优势。