当前位置: X-MOL 学术Ann. Biomed. Eng. › 论文详情
Materials and Microenvironments for Engineering the Intestinal Epithelium.
Annals of Biomedical Engineering ( IF 3.474 ) Pub Date : 2020-02-04 , DOI: 10.1007/s10439-020-02470-8
Jessica Snyder,Chia-Ming Wang,An Qi Zhang,Yuan Li,Joshua Luchan,Sanjin Hosic,Ryan Koppes,Rebecca Lyn Carrier,Abigail Koppes

The barrier functions of the gastrointestinal tract rely in large part on a single layer of columnar intestinal epithelial cells. These epithelial cells are mediators of intestinal homeostasis, regulating and communicating biochemical signals between underlying stromal cells and luminal cues. The development of representative in vitro models to recapitulate the gastrointestinal epithelium is crucial to understanding cell-cell interactions during intestinal homeostasis and dysfunction. Ideally, models would contain microbiota/immune cells, polarized intestinal architecture, multilayered cellular complexity, extracellular matrix, biochemical cues, and mechanical deformation. This review focuses on historical and state of the art biomaterials and substrates used in the field to establish static and fluidic models of the intestinal epithelium. A discussion of conventional adenocarcinoma colon cancer cell lines, primary intestinal epithelial cells derived from organoids, and stromal support cells such as enteric neurons, myofibroblasts, and immune cells, as well as the importance of increasing cellular complexity and future outlook is included.
更新日期:2020-02-04

 

全部期刊列表>>
智控未来
聚焦商业经济政治法律
跟Nature、Science文章学绘图
控制与机器人
招募海内外科研人才,上自然官网
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
湖南大学化学化工学院刘松
上海有机所
李旸
南方科技大学
西湖大学
伊利诺伊大学香槟分校
支志明
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug