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Structural Characteristics and Anticancer Activity In Vitro of Fucoidans from Brown Seaweeds Sargassum miyabei and S. oligocystum
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2020-01-01 , DOI: 10.1007/s10600-020-02938-y
V. V. Surits , R. V. Usoltseva , N. M. Shevchenko , P. D. Thinh , S. P. Ermakova

High-purity fucoidan fractions were obtained from brown seaweeds Sargassum miyabei and S. oligocystum. Both first fractions were mannnogalactofucans; second, galactofucans. Fucoidans from S. miyabei contained acetyls. The isolated polysaccharides were not cytotoxic at concentrations up to 400 μg/mL. Formation and growth of colonies of HT-29 and HCT-116 cells were weakly inhibited by the tested fucoidans. Fucoidans SmiF2, SoF1, and SoF2 had the greatest anticancer effects against the DLD-1 cell line.

中文翻译:

褐海藻 Sargassum miyabei 和 S. oligocystum 褐藻糖胶的结构特征和体外抗癌活性

从棕色海藻 Sargassum miyabei 和 S. oligocystum 中获得高纯度岩藻依聚糖组分。两个第一级分都是甘露半乳糖;第二,半乳糖。来自 S. miyabei 的褐藻糖胶含有乙酰。分离的多糖在高达 400 μg/mL 的浓度下没有细胞毒性。HT-29 和 HCT-116 细胞集落的形成和生长被测试的褐藻糖胶微弱抑制。Fucoidans SmiF2、SoF1 和 SoF2 对 DLD-1 细胞系具有最大的抗癌作用。
更新日期:2020-01-01
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