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Resistance looms for KRASG12C inhibitors.
Nature Medicine ( IF 82.9 ) Pub Date : 2020-02-04 , DOI: 10.1038/s41591-020-0765-z
Aaron N Hata 1 , Alice T Shaw 2
Affiliation  

Cells develop a heterogeneous response to KRAS inhibitors, bypassing their anti-growth effects by producing more of the protein that does not bind the inhibitor.

中文翻译:

KRASG12C抑制剂的耐药性迫在眉睫。

细胞会通过产生更多不与抑制剂结合的蛋白质来绕过KRAS抑制剂的异质反应,从而绕开其抗生长作用。
更新日期:2020-02-04
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