AIMS/HYPOTHESIS This randomised controlled trial was performed in India and the UK in people with prediabetes to study whether mobile phone short message service (SMS) text messages can be used to motivate and educate people to follow lifestyle modifications, to prevent type 2 diabetes. METHODS The study was performed in people with prediabetes (n = 2062; control: n = 1031; intervention: n = 1031) defined by HbA1c ≥42 and ≤47 mmol/mol (≥6.0% and ≤6.4%). Participants were recruited from public and private sector organisations in India (men and women aged 35-55 years) and by the National Health Service (NHS) Health Checks programme in the UK (aged 40-74 years without pre-existing diabetes, cardiovascular disease or kidney disease). Allocation to the study groups was performed using a computer-generated sequence (1:1) in India and by stratified randomisation in permuted blocks in the UK. Investigators in both countries remained blinded throughout the study period. All participants received advice on a healthy lifestyle at baseline. The intervention group in addition received supportive text messages using mobile phone SMS messages 2-3 times per week. Participants were assessed at baseline and at 6, 12 and 24 months. The primary outcome was conversion to type 2 diabetes and secondary outcomes included anthropometry, biochemistry, dietary and physical activity changes, blood pressure and quality of life. RESULTS At the 2 year follow-up (n = 2062; control: n = 1031; intervention: n = 1031), in the intention-to-treat population the HR for development of type 2 diabetes calculated using a discrete-time proportional hazards model was 0.89 (95% CI 0.74, 1.07; p = 0.22). There were no significant differences in the secondary outcomes. CONCLUSIONS/INTERPRETATION This trial in two countries with varied ethnic and cultural backgrounds showed no significant reduction in the progression to diabetes in 2 years by lifestyle modification using SMS messaging. TRIAL REGISTRATION The primary study was registered on www.ClinicalTrials.gov (India, NCT01570946; UK, NCT01795833). FUNDING The study was funded jointly by the Indian Council for Medical Research and the UK Medical Research Council.

中文翻译：

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一种实用且可扩展的策略，使用移动技术促进持续的生活方式改变，以预防印度和英国的2型糖尿病：一项随机对照试验。

目的/假设该随机对照试验在印度和英国的糖尿病前期人群中进行，旨在研究手机短信服务（SMS）短信是否可用于激励和教育人们遵循生活方式的改变，以预防2型糖尿病。方法该研究是在患有HbA1c≥42和≤47mmol / mol（≥6.0％和≤6.4％）的糖尿病前期患者（n = 2062；对照组：n = 1031；干预措施：n = 1031）中进行的。参与者是从印度的公共和私营部门组织（年龄在35-55岁之间的男性和女性）和英国的国家健康服务（NHS）健康检查计划（年龄在40-74岁，没有糖尿病，心血管疾病）中招募的参与者或肾脏疾病）。使用计算机生成的序列（1：1）在印度，并在英国按排列的区块分层随机化。两国的研究人员在整个研究期间均保持盲目状态。所有参与者在基线时都获得了关于健康生活方式的建议。干预小组另外每周使用手机SMS消息接收2-3次支持性文本消息。在基线，第6、12和24个月对参与者进行评估。主要结局是转变为2型糖尿病，而次要结局包括人体测量学，生物化学，饮食和身体活动的变化，血压和生活质量。结果在为期2年的随访中（n = 2062；对照组：n = 1031；干预措施：n = 1031），在意向性治疗人群中，使用离散时间比例风险计算的2型糖尿病发生率模型为0.89（95％CI 0.74，1.07; p = 0.22）。次要结局无明显差异。结论/解释这项在两个种族和文化背景不同的国家进行的试验表明，通过使用SMS短信改变生活方式，在2年内不会使糖尿病的进展显着降低。试验注册初步研究已在www.ClinicalTrials.gov（印度，NCT01570946；英国，NCT01795833）上注册。资助该研究由印度医学研究理事会和英国医学研究理事会共同资助。试验注册初步研究已在www.ClinicalTrials.gov（印度，NCT01570946；英国，NCT01795833）上注册。资助该研究由印度医学研究理事会和英国医学研究理事会共同资助。试验注册初步研究已在www.ClinicalTrials.gov（印度，NCT01570946；英国，NCT01795833）上注册。资助该研究由印度医学研究理事会和英国医学研究理事会共同资助。