AIMS/HYPOTHESIS Prediabetes is associated with postprandial hypertriacylglycerolaemia. Resistance exercise acutely lowers postprandial plasma triacylglycerol (TG); however, the changes in lipid metabolism that mediate this reduction are poorly understood. The aim of this study was to identify the constitutive metabolic mechanisms underlying the changes in postprandial lipid metabolism after resistance exercise in obese men with prediabetes. METHODS We evaluated the effect of a single bout of whole-body resistance exercise (seven exercises, three sets, 10-12 repetitions at 80% of one-repetition maximum) on postprandial lipid metabolism in ten middle-aged (50 ± 9 years), overweight/obese (BMI: 33 ± 3 kg/m2), sedentary men with prediabetes (HbA1c >38 but <48 mmol/mol [>5.7% but <6.5%]), or fasting plasma glucose >5.6 mmol/l but <7.0 mmol/l or 2 h OGTT glucose >7.8 mmol/l but <11.1 mmol/l). We used a randomised, crossover design with a triple-tracer mixed meal test (ingested [(13C4)3]tripalmitin, i.v. [U-13C16]palmitate and [2H5]glycerol) to evaluate chylomicron-TG and total triacylglycerol-rich lipoprotein (TRL)-TG kinetics. We used adipose tissue and skeletal muscle biopsies to evaluate the expression of genes regulating lipolysis and lipid oxidation, skeletal muscle respirometry to evaluate oxidative capacity, and indirect calorimetry to assess whole-body lipid oxidation. RESULTS The single bout of resistance exercise reduced the lipaemic response to a mixed meal in obese men with prediabetes without changing chylomicron-TG or TRL-TG fractional clearance rates. However, resistance exercise reduced endogenous and meal-derived fatty acid incorporation into chylomicron-TG and TRL-TG. Resistance exercise also increased whole-body lipid oxidation, skeletal muscle mitochondrial respiration, oxidative gene expression in skeletal muscle, and the expression of key lipolysis genes in adipose tissue. CONCLUSIONS/INTERPRETATION A single bout of resistance exercise improves postprandial lipid metabolism in obese men with prediabetes, which may mitigate the risk for cardiovascular disease and type 2 diabetes.

中文翻译：

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一次抗性锻炼可以改善超重/肥胖糖尿病前期患者的餐后脂质代谢。

目的/假设前驱糖尿病与餐后高三酰甘油血症有关。抵抗运动会急剧降低餐后血浆三酰甘油（TG）；然而，人们对导致这种减少的脂质代谢的变化知之甚少。这项研究的目的是确定抵抗性运动后肥胖的糖尿病前期男子的餐后脂质代谢变化的本构代谢机制。方法我们评估了十次中年（50±9岁）的一次单次全身抵抗运动（七次练习，三组，以一次重复最大次数的80％重复10-12次）对餐后脂质代谢的影响，超重/肥胖（BMI：33±3 kg / m2），久坐的糖尿病前期患者（HbA1c> 38但<48 mmol / mol [> 5.7％但<6.5％]），或者空腹血糖> 5.6 mmol / l但<7。0 mmol / l或2 h OGTT葡萄糖> 7.8 mmol / l但<11.1 mmol / l）。我们使用了随机，交叉设计和三重示踪混合餐试验（食用[（13C4）3] tripalmitin，iv [U-13C16] palmitate和[2H5]甘油）来评估乳糜微粒TG和总富含三酰基甘油的脂蛋白（ TRL）-TG动力学。我们使用脂肪组织和骨骼肌活组织检查评估调节脂解和脂质氧化的基因表达，骨骼肌呼吸测定法评估氧化能力，间接量热法评估全身脂质氧化。结果单次抵抗运动减少了肥胖男性糖尿病前期患者对混合餐的脂肪反应，而乳糜微粒-TG或TRL-TG清除率却没有改变。然而，抵抗运动减少了乳糜微粒-TG和TRL-TG中内源性和膳食来源的脂肪酸的掺入。抵抗运动还增加了全身脂质氧化，骨骼肌线粒体呼吸，骨骼肌中氧化基因的表达以及脂肪组织中关键脂解基因的表达。结论/解释单次抵抗运动可改善患有糖尿病的肥胖男性的餐后脂质代谢，这可以减轻心血管疾病和2型糖尿病的风险。