Objective To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarkers in patients with and without CA. Background Excess abdominal fat might facilitate progressive changes in nociceptive thresholds causing central sensitization, clinically reflected as CA, which could drive migraine progression. Methods This prospective cohort study included 80 patients with migraine (mean age 39 years, 81.2% female) and 39 non-migraine controls. We analysed each participant’s height, body weight, and body mass index (BMI). The amount and distribution of BF was also assessed by air displacement plethysmography (ADP) and ViScan, respectively. We analysed serum levels of markers of inflammation, during interictal periods. Results We studied 52 patients with episodic migraine (EM) and 28 with chronic migraine (CM). Of the 80 patients, 53 (53.8%) had CA. Migraineurs with CA had a higher proportion of abdominal fat values than patients without CA ( p = 0.04). The independent risk factors for CA were the use of migraine prophylaxis (OR 3.26, 95% CI [1.14 to 9.32]; p = 0.03), proportion of abdominal fat (OR 1.13, 95% CI [1.01 to 1.27]; p = 0.04), and presence of sleep disorders (OR 1.13, 95% CI [00.01 to 1.27]; p = 0.04). The concordance correlation coefficient between the ADP and BMI measurements was 0.51 (0.3681 to 0.6247). CA was not correlated with the mean plasma levels of inflammatory biomarkers. Conclusions There is a relation between excess abdominal fat and CA. Abdominal obesity might contribute to the development of central sensitization in migraineurs, leading to migraine chronification.

中文翻译：

---

过多的腹部脂肪与偏头痛患者的皮肤异常性疼痛有关：一项前瞻性队列研究

目的探讨偏头痛患者皮肤异常性疼痛（CA）与体脂（BF）、腹部脂肪百分比的具体关系。此外，我们比较了有和没有 CA 患者的炎症生物标志物的血清水平。背景 过多的腹部脂肪可能会促进痛觉阈值的逐渐变化，导致中枢敏化，临床反映为 CA，这可能会导致偏头痛进展。方法 这项前瞻性队列研究包括 80 名偏头痛患者（平均年龄 39 岁，81.2% 为女性）和 39 名非偏头痛对照者。我们分析了每个参与者的身高、体重和体重指数 (BMI)。BF 的数量和分布也分别通过空气置换体积描记法 (ADP) 和 ViScan 进行评估。我们分析了炎症标志物的血清水平，在间歇期。结果 我们研究了 52 名发作性偏头痛 (EM) 和 28 名慢性偏头痛 (CM) 患者。在 80 名患者中，53 名 (53.8%) 患有 CA。与没有 CA 的患者相比，患有 CA 的偏头痛患者的腹部脂肪值比例更高 (p = 0.04)。CA 的独立危险因素是偏头痛预防的使用（OR 3.26，95% CI [1.14 至 9.32]；p = 0.03）、腹部脂肪比例（OR 1.13，95% CI [1.01 至 1.27]；p = 0.04 )，以及存在睡眠障碍（OR 1.13，95% CI [00.01 至 1.27]；p = 0.04）。ADP 和 BMI 测量值之间的一致性相关系数为 0.51（0.3681 至 0.6247）。CA 与炎症生物标志物的平均血浆水平无关。结论腹部脂肪过多与CA之间存在相关性。