Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and shedding of the ectodomain of many transmembrane receptors often accompany inflammatory states. The shedding mostly occurs through cleavage by a disintegrin-and-metalloproteinase-17 (ADAM-17), an enzyme activated by inflammation. It reduces the cellular uptake of TG-loaded lipoproteins, causing their accumulation in circulation; hence the correlation between plasma sLDLR and TG. Soluble LDLR could become a new surrogate marker of inflammation.

中文翻译：

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可溶性LDLR的谜团：炎症可能是关键吗？

可溶性低密度脂蛋白受体（sLDLR）是跨膜LDLR的循环胞外域。它的血液水平与甘油三酸酯（TG）高度相关。这种相关性还没有令人满意的解释。高甘油三酸酯血症和许多跨膜受体胞外域的脱落通常伴有炎症状态。脱落主要是通过解整合素和金属蛋白酶17（ADAM-17）的切割而发生的，该酶是一种由炎症激活的酶。它减少了载有TG的脂蛋白的细胞摄取，导致其在循环中的积累；因此血浆sLDLR与TG之间的相关性。可溶性LDLR可能成为炎症的新替代指标。