Lung cancer (LC) is the leading cause of cancer-related death worldwide due to its late diagnosis and poor outcomes. As has been found for other types of tumors, there is increasing evidence that myeloid-derived suppressor cells (MDSCs) play important roles in the promotion and progression of LC. Here, we briefly introduce the definition of MDSCs and their immunosuppressive functions. We next specifically discuss the multiple roles of MDSCs in the lung tumor microenvironment, including those in tumor growth and progression mediated by inhibiting antitumor immunity, and the associations of MDSCs with a poor prognosis and increased resistance to chemotherapy and immunotherapy. Finally, we also discuss preclinical and clinical treatment strategies targeting MDSCs, which may have the potential to enhance the efficacy of immunotherapy.

中文翻译：

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骨髓来源的抑制细胞是肺癌中令人兴奋的新分子。

肺癌（LC）由于其诊断晚和结果差而成为全球癌症相关死亡的主要原因。正如针对其他类型肿瘤的发现一样，越来越多的证据表明，髓样来源的抑制细胞（MDSC）在LC的促进和进展中起着重要作用。在这里，我们简要介绍MDSC的定义及其免疫抑制功能。接下来，我们专门讨论MDSCs在肺肿瘤微环境中的多种作用，包括在抑制抗肿瘤免疫介导的肿瘤生长和进展中的作用，以及MDSCs与不良预后以及对化学疗法和免疫疗法的抵抗力增加之间的关系。最后，我们还讨论了针对MDSC的临床前和临床治疗策略，这些策略可能具有增强免疫治疗功效的潜力。