INTRODUCTION Pediatric z scores are necessary to describe size and structure of the heart in growing children, however, development of an accurate z score calculator requires robust normal datasets, which are difficult to obtain with cardiovascular magnetic resonance (CMR) in children. Motion-corrected (MOCO) cines from re-binned, reconstructed real-time cine offer a free-breathing, rapid acquisition resulting in cines with high spatial and temporal resolution. In combination with child-friendly positioning and entertainment, MOCO cine technique allows for rapid cine volumetry in patients of all ages without sedation. Thus, our aim was to prospectively enroll normal infants and children birth-12 years for creation and validation of a z score calculator describing normal right ventricular (RV) and left ventricular (LV) size. METHODS With IRB approval and consent/assent, 149 normal children successfully underwent a brief noncontrast CMR on a 1.5 T scanner including MOCO cines in the short axis, and RV and LV volumes were measured. 20% of scans were re-measured for interobserver variability analyses. A general linear modeling (GLM) framework was employed to identify and properly represent the relationship between CMR-based assessments and anthropometric data. Scatter plots of model fit and Akaike's information criteria (AIC) results were used to guide the choice among alternative models. RESULTS A total of 149 subjects aged 22 days-12 years (average 5.1 ± 3.6 years), with body surface area (BSA) range 0.21-1.63 m2 (average 0.8 ± 0.35 m2) were scanned. All ICC values were > 95%, reflecting excellent agreement between raters. The model that provided the best fit of volume measure to the data included BSA with higher order effects and gender as independent variables. Compared with earlier z score models, there is important additional growth inflection in early toddlerhood with similar z score prediction in later childhood. CONCLUSIONS Free-breathing, MOCO cines allow for accurate, reliable RV and LV volumetry in a wide range of infants and children while awake. Equations predicting fit between LV and RV normal values and BSA are reported herein for purposes of creating z scores. TRIAL REGISTRATION clinicaltrials.gov NCT02892136, Registered 7/21/2016.

中文翻译：

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预期从清醒，健康的0-12岁儿童的心血管磁共振获得正常的右，左心室容积。

简介小儿z评分是描述成长中儿童心脏大小和结构所必需的，但是，开发准确的z评分计算器需要健全的正常数据集，而儿童的心血管磁共振（CMR）很难获得这些数据。来自重新组合，重建的实时电影的运动校正（MOCO）电影提供了自由呼吸，快速的采集效果，从而使电影具有高时空分辨率。结合适合儿童的定位和娱乐功能，MOCO电影技术可在不使用镇静剂的情况下为所有年龄段的患者提供快速的电影量。因此，我们的目的是前瞻性招募12岁以下的正常婴儿和儿童，以创建和验证描述正常右心室（RV）和左心室（LV）大小的z评分计算器。方法经IRB批准和同意/同意，对149名正常儿童在1.5 T扫描仪上成功进行了简短的非对比CMR，包括短轴MOCO电影，并测量了RV和LV量。重新测量了20％的扫描，以进行观察者之间的变异性分析。使用通用线性建模（GLM）框架来识别并正确表示基于CMR的评估与人体测量数据之间的关系。模型拟合的散点图和Akaike的信息标准（AIC）结果用于指导在替代模型中进行选择。结果总共对149位年龄22天至12岁（平均5.1±3.6岁），体表面积（BSA）为0.21-1.63 m2（平均0.8±0.35 m2）的受试者进行了扫描。所有ICC值均> 95％，反映了评估者之间的高度一致性。为数据提供最佳体积度量的模型包括具有较高阶效应的BSA，并且性别作为自变量。与早期的z评分模型相比，幼儿期存在重要的额外增长拐点，而在儿童后期的z评分预测相似。结论MOCO电影可以自由呼吸，可以在清醒时为各种婴儿和儿童提供准确，可靠的RV和LV量。为了产生z分数，在本文中报道了预测LV和RV正常值与BSA之间的拟合的方程式。试验注册临床试验.gov NCT02892136，注册日期：2016年7月21日。在幼儿期，还有重要的额外增长拐点，而在儿童后期，z得分预测相似。结论MOCO电影可以自由呼吸，可以在清醒时为各种婴儿和儿童提供准确，可靠的RV和LV量。为了产生z分数，在本文中报道了预测LV和RV正常值与BSA之间的拟合的方程式。试验注册临床试验.gov NCT02892136，注册日期：2016年7月21日。在幼儿期，重要的额外增长拐点在儿童后期具有相似的z得分预测。结论MOCO电影可以自由呼吸，可以在清醒时为各种婴儿和儿童提供准确，可靠的RV和LV量。为了产生z分数，在本文中报道了预测LV和RV正常值与BSA之间的拟合的方程式。试验注册临床试验.gov NCT02892136，注册日期：2016年7月21日。