BACKGROUND Approximately 80% of patients with indwelling ureteral stents experience stent related symptoms (SRS). We believe SRS can be reduced through altering the composition of ureteral stents to a less firm material. Therefore, we aim to compare modern silicone and polyurethane ureteral stents in terms of SRS intensity and safety. METHODS From June 2018 to October 2018, patients from two distinct clinical centers were prospectively enrolled in the study and stratified (non-randomly) into either control group A, patients who received polyurethane stents (Rüsch, Teleflex), or experimental group B, patients who received silicone stents (Cook Medical). Each participant completed a survey 1 h after stent insertion, in the middle of the stent dwelling period, and before stent removal or ureteroscopy noting body pain and overactive bladder via the visual analog scale pain (VASP) and overactive bladder (OAB) awareness tool, respectively. Additionally, successfulness of stent placement, hematuria, number of unplanned visits, and stent encrustation rates were assessed within each group. RESULTS A total of 50 patients participated in the study, control group A consisted of 20 patients and experimental group B consisted of 30 patients. Participants in group B, silicone ureteral stents, demonstrated significantly lower mean values of VASP 2 weeks prior to stent removal and promptly before stent removal (p = 0.023 and p = 0.014, respectively). No other comparisons between the two groups were statistically significant. CONCLUSIONS Compared to polyurethane ureteral stents, silicone ureteral stents are associated with lower body pain intensity assessed by VASP 2 weeks before stent removal and at the time of stent removal. TRIAL REGISTRATION Current Controlled Trials NCT04000178. Retrospectively registered on June 26, 2019.

中文翻译：

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硅胶和聚氨酯输尿管支架的比较：一项前瞻性对照研究。

背景技术约有80％的留置输尿管支架的患者经历支架相关症状（SRS）。我们认为，可以通过将输尿管支架的组成改为较不牢固的材料来减少SRS。因此，我们旨在从SRS强度和安全性方面比较现代的硅胶和聚氨酯输尿管支架。方法从2018年6月至2018年10月，将来自两个不同临床中心的患者前瞻性纳入研究，并将其分层（非随机）分为对照组A，接受聚氨酯支架（Rüsch，Teleflex）或实验B组谁接受了硅胶支架（库克医疗公司）。每位参与者在置入支架1小时后，在支架停留期间的中间完成一次调查，以及在移除支架或输尿管镜检查之前，分别通过视觉模拟鳞片疼痛（VASP）和膀胱过度活动症（OAB）意识工具观察身体疼痛和膀胱过度活动症。此外，在每个组中评估了支架放置，血尿，计划外就诊次数和支架结壳率的成功率。结果共有50例患者参加了研究，对照组A包括20例患者，实验组B由30例患者组成。B组的参与者，硅胶输尿管支架，在支架拆除前两周和支架拆除前即刻均表现出明显较低的VASP平均值（分别为p = 0.023和p = 0.014）。两组之间没有其他比较具有统计学意义。结论与聚氨酯输尿管支架相比，硅胶输尿管支架与下支架去除前2周和支架去除时通过VASP评估的下肢疼痛强度有关。试用注册电流控制试验NCT04000178。追溯注册于2019年6月26日。