BACKGROUND Executive function (EF) is vital to human beings. It has been linked to many genes and family environmental factors in separate studies, but few studies have examined the potential interactions between gene(s) and environmental factor(s). The current study explored the whole genome to identify SNPs, genes, and pathways that interacted with parental warmth (PW) on EF. RESULTS Nine EF tasks were used to measure its three components (common EF, updating, shifting) based on the model proposed by Miyake et al. (2000). We found that rs111605473, LAMP5, SLC4A7, and LRRK1 interacted significantly with PW to affect the updating component of EF, and the GSE43955 pathway interacted significantly with PW to affect the common EF component. CONCLUSIONS The current study is the first to identify genes that interacted with PW to affect EF. Further studies are needed to reveal the underlying mechanism.

中文翻译：

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父母的温暖与几种基因相互作用以影响执行功能组件：一项全基因组环境相互作用研究。

背景技术执行功能（EF）对人类至关重要。在单独的研究中，它已与许多基因和家庭环境因素联系在一起，但很少有研究检查基因与环境因素之间的潜在相互作用。当前的研究探索了整个基因组，以鉴定与EF上的父母亲（PW）相互作用的SNP，基因和途径。结果在Miyake等人提出的模型的基础上，九个EF任务用于测量其三个组成部分（通用EF，更新，转移）。（2000）。我们发现rs111605473，LAMP5，SLC4A7和LRRK1与PW显着相互作用，以影响EF的更新组件，而GSE43955途径与PW显着相互作用，以影响常见的EF组件。结论当前的研究是第一个鉴定与PW相互作用以影响EF的基因的研究。