Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcriptional regulator in the response to hypoxia, has been demonstrated to significantly modulate hypoxic gene expression and signaling transduction networks. In past few decades, growing numbers of studies have revealed the importance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. These hypoxia-responsive ncRNAs (HRNs) play pivotal roles in regulating hypoxic gene expression at the transcriptional, posttranscriptional, translational and posttranslational levels. In addition, as a significant gene expression regulator, ncRNAs exhibit promising roles in regulating HIF-1α expression at multiple levels. In this review, we briefly elucidate the reciprocal regulation between HIF-1α and ncRNAs, as well as their effect on cancer cell behaviors. We also try to summarize the complex feedback loop existing between these two components. Moreover, we evaluated the biomarker potential of HRNs for the diagnosis and prognosis of cancer, as well as the potential clinical utility of shared regulatory mechanisms between HIF-1α and ncRNAs in cancer treatment, providing novel insights into tumorigenicity, which may lead to innovative clinical applications.

中文翻译：

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HIF-1α与非编码RNA在癌症中的相互作用。

缺氧是肿瘤微环境的经典特征，对癌症的进展和治疗反应具有重大影响。缺氧诱导因子-1α（HIF-1α）是缺氧反应中最重要的转录调节因子，已被证明可显着调节缺氧基因的表达和信号转导网络。在过去的几十年中，越来越多的研究揭示了缺氧肿瘤区域中非编码RNA（ncRNA）的重要性。这些缺氧反应性ncRNA（HRN）在转录，转录后，翻译和翻译后水平上调节缺氧基因表达起关键作用。另外，作为重要的基因表达调节剂，ncRNA在多种水平的HIF-1α表达调节中显示出有希望的作用。在这篇评论中 我们简要阐明了HIF-1α和ncRNA之间的相互调节，以及它们对癌细胞行为的影响。我们还尝试总结这两个组件之间存在的复杂反馈回路。此外，我们评估了HRNs在癌症诊断和预后中的生物标志物潜力，以及HIF-1α和ncRNA之间共享的调控机制在癌症治疗中的潜在临床效用，从而提供了关于致癌性的新见解，这可能会导致创新的临床研究应用程序。