Compared with painful and difficult overall weight-loss, a surgery-free method was developed to achieve local accurate body slimming. A layer of black phosphorus was modified on the back of the rosiglitazone (Rosi)-loaded soluble microneedle patch. Under near-infrared (NIR) irradiation, Rosi could be delivered to the target adipose tissues efficiently and painlessly, thus achieving accurate body slimming. Based on the experiments in a mouse model with high-fat-induced obesity, after one month, the mice lost about 8% of their body weight while their waist circumference (target region) dropped about 21%. In addition, an interesting phenomenon of adipose tissue dynamic compensation was discovered and discussed for the first time.

与痛苦和困难的总体减肥相比，开发了一种无需手术的方法来实现局部精确的减肥。在装载了罗格列酮（Rosi）的可溶性微针贴片的背面修饰了一层黑磷。在近红外（NIR）辐射下，Rosi可以高效且无痛地输送到目标脂肪组织，从而实现精确的减肥。根据高脂诱导肥胖小鼠模型的实验，一个月后，小鼠体重减轻了约8％，而腰围（目标区域）降低了约21％。此外，首次发现并讨论了有趣的脂肪组织动态补偿现象。