当前位置: X-MOL 学术Clin. Psychol. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention.
Clinical Psychology Review ( IF 12.8 ) Pub Date : 2020-02-04 , DOI: 10.1016/j.cpr.2020.101830
Miriam A Schiele 1 , Michael G Gottschalk 1 , Katharina Domschke 2
Affiliation  

Mental disorders are highly complex and multifactorial in origin, comprising an elaborate interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA modifications (e.g. CpG methylation), histone modifications (e.g. acetylation) and microRNAs function as a translator between genes and the environment. Indeed, environmental influences such as exposure to stress shape epigenetic patterns, and lifetime experiences continue to alter the function of the genome throughout the lifespan. Here, we summarize the recently burgeoning body of research regarding the involvement of aberrant epigenetic signatures in mediating an increased vulnerability to a wide range of mental disorders. We review the current knowledge of epigenetic changes to constitute useful markers predicting the clinical response to psychotherapeutic interventions, and of psychotherapy to alter – and potentially reverse – epigenetic risk patterns. Given first evidence pointing to a transgenerational transmission of epigenetic information, epigenetic alterations arising from successful psychotherapy might be transferred to future generations and thus contribute to the prevention of mental disorders. Findings are integrated into a multi-level framework highlighting challenges pertaining to the mechanisms of action and clinical implications of epigenetic research. Promising future directions regarding the prediction, prevention, and personalized treatment of mental disorders in line with a ‘precision medicine’ approach are discussed.



中文翻译:

表观遗传学在焦虑,情感和与压力有关的疾病中的应用意义-社会心理压力,心理治疗和预防的综述和综合。

精神障碍是高度复杂和多因素的起源,包括遗传因素和环境因素的复杂相互作用。表观遗传机制(例如DNA修饰(例如CpG甲基化),组蛋白修饰(例如乙酰化)和microRNA)充当基因与环境之间的翻译器。确实,环境影响(例如暴露于应激会影响表观遗传模式)和一生的经历不断改变着整个生命周期中基因组的功能。在这里,我们总结了有关异常表观遗传学信号参与介导对多种精神障碍的增加的脆弱性的研究,这些研究正在迅速发展。我们回顾了表观遗传学变化的最新知识,以构成预测心理治疗干预措施临床反应的有用标记,以及通过心理疗法来改变(并可能逆转)表观遗传风险模式。如果有第一个证据表明表观遗传信息可以跨代传播,那么成功的心理治疗所产生的表观遗传改变可能会转移到子孙后代,从而有助于预防精神疾病。研究结果被整合到一个多层次的框架中,突出显示了与表观遗传研究的作用机制和临床意义有关的挑战。讨论了根据“精密医学”方法对精神障碍的预测,预防和个性化治疗的有前途的未来方向。成功的心理治疗所产生的表观遗传学改变可能会转移到子孙后代,从而有助于预防精神疾病。研究结果被整合到一个多层次的框架中,突出显示了与表观遗传研究的作用机制和临床意义有关的挑战。讨论了根据“精密医学”方法对精神障碍的预测,预防和个性化治疗的有前途的未来方向。成功的心理治疗所产生的表观遗传学改变可能会转移到子孙后代,从而有助于预防精神疾病。研究结果被整合到一个多层次的框架中,突出显示了与表观遗传研究的作用机制和临床意义有关的挑战。讨论了根据“精密医学”方法对精神障碍的预测,预防和个性化治疗的有前途的未来方向。

更新日期:2020-02-04
down
wechat
bug