Deficiency of glucose, even under sufficient amino acid supply, turns off translation and promotes catabolic processes to aid cell survival. A recent report by Yoon et al. (2020) shows that glucose is required for the full activity of the leucyl-tRNA synthetase LARS1 and maintains mTORC1 function via LARS1 to enhance translation. Glucose starvation abolishes both effects via phosphorylation of LARS1 by the AMPK-ULK1 signaling pathway. This study supports the idea that glucose starvation inhibits translation at multiple levels.

中文翻译：

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葡萄糖饥饿会在多个层面上阻碍翻译。

葡萄糖缺乏，即使在氨基酸供应充足的情况下，也会关闭翻译并促进分解代谢过程，以帮助细胞生存。Yoon 等人最近的一份报告。(2020) 表明亮氨酰-tRNA 合成酶 LARS1 的全部活性需要葡萄糖，并通过 LARS1 维持 mTORC1 功能以增强翻译。葡萄糖饥饿通过 AMPK-ULK1 信号通路磷酸化 LARS1 消除这两种效应。这项研究支持了葡萄糖饥饿在多个水平上抑制翻译的观点。