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Potential application of liposomal nanodevices for non-cancer diseases: an update on design, characterization and biopharmaceutical evaluation.
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2020-02-04 , DOI: 10.1016/j.cis.2020.102121
Fereshteh Bayat 1 , Reza Hosseinpour-Moghadam 1 , Fatemeh Mehryab 1 , Yousef Fatahi 2 , Niayesh Shakeri 1 , Rassoul Dinarvand 3 , Timo L M Ten Hagen 4 , Azadeh Haeri 5
Affiliation  

Liposomes, lipid-based vesicular systems, have attracted major interest as a means to improve drug delivery to various organs and tissues in the human body. Recent literature highlights the benefits of liposomes for use as drug delivery systems, including encapsulating of both hydrophobic and hydrophilic cargos, passive and active targeting, enhanced drug bioavailability and therapeutic effects, reduced systemic side effects, improved cargo penetration into the target tissue and triggered contents release. Pioneering work of liposomes researchers led to introduction of long-circulating, ligand-targeted and triggered release liposomes, as well as, liposomes containing nucleic acids and vesicles containing combination of cargos. Altogether, these findings have led to widespread application of liposomes in a plethora of areas from cancer to conditions such as cardiovascular, neurologic, respiratory, skin, autoimmune and eye disorders. There are numerous review articles on the application of liposomes in treatment of cancer, which seems the primary focus, whereas other diseases also benefit from liposome-mediated treatments. Therefore, this article provides an illustrated detailed overview of liposomal formulations, in vitro characterization and their applications in different disorders other than cancer. Challenges and future directions, which must be considered to obtain the most benefit from applications of liposomes in these disorders, are discussed.

中文翻译:

脂质体纳米装置在非癌症疾病中的潜在应用:设计,表征和生物药物评估的最新进展。

脂质体(基于脂质的囊泡系统)作为一种改善药物向人体各种器官和组织的输送的手段,引起了人们的极大兴趣。最近的文献强调了脂质体用作药物传递系统的好处,包括包裹疏水和亲水的货物,被动和主动靶向,增强的药物生物利用度和治疗效果,减少的全身性副作用,改善的货物透入靶组织和触发内含物发布。脂质体研究人员的开拓性工作导致引入了长循环,靶向配体和触发释放的脂质体,以及包含核酸的脂质体和包含货物组合的囊泡。共,这些发现导致脂质体在从癌症到诸如心血管,神经,呼吸,皮肤,自身免疫和眼睛疾病等疾病的众多领域中得到广泛应用。关于脂质体在癌症治疗中的应用,有许多评论文章,这似乎是主要焦点,而其他疾病也可从脂质体介导的治疗中受益。因此,本文提供了脂质体制剂,体外表征及其在癌症以外的其他疾病中的应用的详细图解说明。讨论了必须考虑的挑战和未来方向,才能从脂质体在这些疾病中的应用中获得最大收益。关于脂质体在癌症治疗中的应用,有许多评论文章,这似乎是主要焦点,而其他疾病也可从脂质体介导的治疗中受益。因此,本文提供了脂质体制剂,体外表征及其在癌症以外的其他疾病中的应用的详细图解说明。讨论了必须考虑的挑战和未来方向,才能从脂质体在这些疾病中的应用中获得最大收益。关于脂质体在癌症治疗中的应用,有许多评论文章,这似乎是主要焦点,而其他疾病也可从脂质体介导的治疗中受益。因此,本文提供了脂质体制剂,体外表征及其在癌症以外的其他疾病中的应用的详细图解说明。讨论了必须考虑的挑战和未来方向,才能从脂质体在这些疾病中的应用中获得最大收益。
更新日期:2020-02-04
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