Background and Objectives: The world’s second largest permanent hypersaline lake, Lake Urmia, is drying in recent years and the dried bed of the Lake acts as a hypersaline particle emission source. Therefore, we aim to evaluate (for the first time to our knowledge) the association between hypersaline particles and biomarkers of inflammation and coagulation (hs-CRP and fibrinogen) in the residents around the Lake Urmia.

Methods: Three regions were selected as clean (region No.1) and polluted regions (region No.2 and No.3) for ambient particulate matter around the Urmia Lake from 2008 to 2015. In order to confirm the selected regions concentration of APM was measured in the selected regions for six months. Totally 123 participants were selected randomly, fibrinogen, hs-CRP and covariates were measured in the selected regions and were analyzed using multiple linear regression models.

Results: We found a statistically significant association between the hypersaline particles and fibrinogen in both polluted regions. This is while an association between hypersaline particles and hs-CRP was significant only in the polluted region No.2.

Conclusions: These results are consistent with our hypothesis that long-term exposure to hypersaline particles originated from drying Urmia hypersaline Lake is related to increased levels of hs-CRP and fibrinogen.

背景与目标：近年来，世界第二大永久性高盐湖Urmia湖正在干燥，湖的干燥床成为高盐颗粒物的排放源。因此，我们的目标是（首次就我们所知）评估高盐度颗粒与Urmia湖附近居民的炎症和凝血生物标志物（hs-CRP和纤维蛋白原）之间的关联。

方法：选择2008年至2015年乌尔米亚湖周围3个区域的洁净颗粒物（第1区域）和污染区域（第2和第3区域）。以确认所选区域的APM浓度在选定区域进行了六个月的测量。总共随机选择了123名参与者，在所选区域中测量了纤维蛋白原，hs-CRP和协变量，并使用多个线性回归模型进行了分析。

结果：我们在两个污染区的高盐颗粒和纤维蛋白原之间发现了统计学上显着的关联。而高盐颗粒与hs-CRP之间的关联仅在2号污染区域才显着。

结论：这些结果与我们的假设一致，即长期暴露于干燥的Urmia hypersaline Lake引起的高盐颗粒与hs-CRP和纤维蛋白原水平升高有关。