OBJECTIVES This study is aimed to analyze the survival differences among patients with lung basaloid squamous cell carcinoma (BSCC), keratinizing squamous cell carcinoma (KSCC), and nonkeratinizing squamous cell carcinoma (NKSCC), and explore the prognostic factors of patients with lung BSCC. MATERIALS AND METHODS We searched the information of 4743 patients with lung SCC between 2005 and 2014 from the SEER database. Propensity score matching (PSM) was used to adjust confounding factors. The overall survival (OS), cancer-specific survival (CSS), and cumulative incidence of cancer-specific mortality (CSM) were estimated with a comparative analysis. A competing risks regression model was conducted to identify the prognostic factors of lung BSCC. RESULTS After PSM, patients with lung BSCC had a higher CSS rate than those with lung KSCC or NKSCC (5-year CSS rate: 50.4 % vs. 37.7 % vs. 38.5 %, p = 0.033 and p = 0.033). The cumulative incidence of CSM was lower for patients with lung BSCC than those with lung KSCC or NKSCC (5-year CSM rate: 46.4 % vs. 56.9 % vs. 56.4 %, p = 0.046 and p = 0.042), which were similar to the results before PSM. As for patients with lung KSCC and NKSCC, there was no survival differences between them (5-year CSS rate: 37.7 % vs. 38.5 %, p = 0.997). The competing risks regression analysis showed that T stage, N stage, M stage and surgery were independent prognostic factors for patients with lung BSCC (all p < 0.05). CONCLUSIONS Patients with lung BSCC had a better survival than those with lung KSCC or NKSCC, while no survival differences were found between lung KSCC and NKSCC. T stage, N stage, M stage and surgery were independent prognostic factors for patients with lung BSCC.

中文翻译：

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肺鳞癌的三种组织学亚型的生存比较：基于人群的倾向得分匹配分析。

目的本研究旨在分析肺基底基底样鳞癌（BSCC），角化鳞状鳞癌（KSCC）和非角化鳞状鳞癌（NKSCC）患者的生存差异，并探讨肺癌BSCC患者的预后因素。材料与方法我们从SEER数据库中检索了2005年至2014年之间的4743例肺SCC患者的信息。倾向得分匹配（PSM）用于调整混杂因素。通过比较分析评估了总生存期（OS），癌症特异性生存期（CSS）和癌症特异性死亡率的累积发生率（CSM）。进行竞争风险回归模型以确定肺BSCC的预后因素。结果在PSM之后，肺BSCC患者的CSS发生率高于肺KSCC或NKSCC的患者（5年CSS发生率：50.4％比37.7％对38.5％，p = 0.033和p = 0.033）。肺BSCC患者的CSM累积发生率低于肺KSCC或NKSCC患者（5年CSM率：46.4％vs. 56.9％vs. 56.4％，p = 0.046和p = 0.042），与PSM之前的结果。至于肺部KSCC和NKSCC患者，两者之间没有生存差异（5年CSS率：37.7％vs. 38.5％，p = 0.997）。竞争风险回归分析显示，T期，N期，M期和手术是肺癌BSCC患者的独立预后因素（所有p <0.05）。结论肺BSCC患者的生存率优于肺KSCC或NKSCC，而肺KSCC和NKSCC的生存率无差异。