Various animal models are used to study pharmacokinetics (PK) of drugs in development. Human renal clearance (CLr) should be predictable through interpolation from animal data by allometric scaling. Based on this premise, we quantified interspecies differences in CLr, and related them to drug properties. Using PubMed and EMBASE, we systematically reviewed literature on human and animal CLr measures for 20 renally excreted drugs, calculated average fold errors, and quantified mean differences between animals and humans. Our results show that animal models are generally good predictors for human drug clearance using simple allometry, except for rats, with which human CLr is significantly overestimated.

中文翻译：

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人类是动物，但动物足够人类吗？有关种间差异的肾脏药物清除的系统评价和荟萃分析。

各种动物模型用于研究正在开发的药物的药代动力学（PK）。人肾清除率（CLr）应该可以通过异速缩放从动物数据中进行插值来预测。在此前提下，我们量化了CLr的种间差异，并将其与药物特性相关联。使用PubMed和EMBASE，我们系统地回顾了有关20种肾脏排泄药物的人和动物CLr量度的文献，计算了平均倍数错误，并量化了人与动物之间的均值差异。我们的结果表明，除了大鼠外，动物模型通常是使用简单异构法进行人药物清除的良好预测指标，而大鼠的人CLr被高估了。