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Can the Injected Dose Be Reduced in 68Ga-PSMA-11 PET/CT While Maintaining High Image Quality for Lesion Detection?
The Journal of Nuclear Medicine ( IF 9.3 ) Pub Date : 2020-02-01 , DOI: 10.2967/jnumed.119.227207
Isabel Rauscher , Wolfgang P. Fendler , Thomas A. Hope , Andrew Quon , Stephan G. Nekolla , Jeremie Calais , Antonia Richter , Bernhard Haller , Ken Herrmann , Wolfgang A. Weber , Johannes Czernin , Matthias Eiber

Our purpose was to define a clinically useful lower limit of injected dose for 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT imaging of prostate cancer. Methods: 68Ga-PSMA-11 PET/CT was performed on 11 patients. PET was acquired in list mode and reconstructed using a 3-min full acquisition, a 2-min acquisition, and a 1-min acquisition to generate images obtained with three thirds (standard dose), two thirds (low dose), and one third (very low dose) of the injected dose, respectively. Overall image quality (5-point scale) was assessed, and the detectability of PSMA-positive lesions was determined by 3 readers and compared with the reference standard. Results: Image quality declined with decreasing dose (mean score of 4.1 ± 0.4 for the standard dose, 3.4 ± 0.7 for the low dose, and 1.9 ± 0.4 for the very low dose; all P < 0.05). Readers 1, 2, and 3 correctly identified the lesions (n = 21) at a rate of 100%, 100%, and 95% with the standard dose; 95%, 81%, and 90% with the low dose; and 71%, 76%, and 59% with the very low dose, respectively. Conclusion: 68Ga-PSMA-11 dose reduction is not feasible without a negative impact on image quality and lesion detectability.



中文翻译:

可以在保持病灶检测的高图像质量的同时,在68 Ga-PSMA-11 PET / CT中减少注射剂量吗?

我们的目的是为前列腺癌的68 Ga前列腺特异性膜抗原(PSMA)-11 PET / CT成像定义临床上有用的注射剂量下限。方法: 对11例患者进行了68例Ga-PSMA-11 PET / CT检查。以列表模式采集PET,并使用3分钟的全采集,2分钟的采集和1分钟的采集进行重建,以生成三分之三(标准剂量),三分之二(低剂量)和三分之一的图像。 (非常低的剂量)。评估整体图像质量(5分制),并由3位读者确定PSMA阳性病变的可检测性,并将其与参考标准进行比较。结果:图像质量随剂量降低而下降(标准剂量的平均评分为4.1±0.4,低剂量的平均评分为3.4±0.7,而非常低的剂量平均评分为1.9±0.4;所有P <0.05)。读者1、2和3以标准剂量分别以100%,100%和95%的比率正确识别出病变(n = 21);低剂量时分别为95%,81%和90%;剂量非常低时分别为71%,76%和59%。结论: 68 Ga-PSMA-11剂量的减少对图像质量和病变可检测性没有负面影响是不可行的。

更新日期:2020-02-03
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