Background

There is a dearth of information about operative outcomes in patients ≥80 years for hepatocellular carcinoma (HCC) from Western institutions. We compare the result of HCC resections in patients <80 years vs. patients ≥80 years from our institution in the UK.

Methods

We conducted a retrospective review of all patients undergoing liver resections for HCC between 2005 and 2015. Demographics, comorbidities, morbidity, mortality and survival were compared between the two age groups.

Results

200 patients underwent resection for HCC in this time period. Nineteen patients were ≥80 years and 181 were <80 years. Comorbidities measured by the Charlson Comorbidity Index were significantly higher in the ≥80 group (p < 0.0001). There was no significant difference in the extent of resection in the two groups. Morbidity and mortality between the <80 years and the ≥80 years group were not significantly different (morbidity 27% vs.16%; p = 0.29) (mortality 7% vs. 0%; p = 0.11). The one-year (83.4% vs. 88.2%; p = 0.83), five-year (56.3% vs. 55.8%; p = 0.83) and the overall survival rate rates (887 days vs. 1035 days; p = 0.66) were not significantly different between the groups.

Discussion

Liver resection should not be precluded based on age alone; with good outcomes in patients ≥80 years justifying surgery.

中文翻译：

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八十多岁的肝细胞癌肝切除术的结果。

背景

西方机构缺乏关于 80 岁以上肝细胞癌 (HCC) 患者手术结果的信息。我们比较了来自我们英国机构的<80 岁患者与80 岁以上患者的 HCC 切除结果。

方法

我们对 2005 年至 2015 年间因 HCC 接受肝切除术的所有患者进行了回顾性研究。比较了两个年龄组的人口统计学、合并症、发病率、死亡率和存活率。

结果

在此期间，200 名患者接受了 HCC 切除术。19 名患者≥80 岁，181 名患者<80 岁。≥ 80 组的 Charlson 合并症指数测量的合并症显着更高（p < 0.0001）。两组切除范围无显着差异。<80 岁组和 80 岁以上组的发病率和死亡率没有显着差异（发病率 27% 对 16%；p = 0.29）（死亡率 7% 对 0%；p = 0.11）。一年（83.4%对88.2%；p = 0.83）、五年（56.3%对55.8%；p = 0.83）和总生存率（887 天对1035 天；p = 0.66）组之间没有显着差异。

讨论

不应仅根据年龄就排除肝切除术；在 80 岁以上的患者中具有良好的结果，证明手术是合理的。