The reaction of diorganotin(IV) with ligands (HL¹ = 3-aminopyridine-2-carbaldehyde N(4) methylthiosemicarbazone, HL² = 3-aminopyridine-2-carbaldehyde N(4)-dimethylthiosemicarbazone) afforded two compounds [PhSn(L¹)Cl₂] (1) and [(Ph)₂Sn(L²)Cl] (2), respectively. The compounds were characterized by elemental analysis, infrared spectrum, UV–vis spectrometry, and X-ray crystallography. The ligands and corresponding complexes were assayed for their in vitro pharmaceutical activity against different pathogenic strains of bacteria by disk diffusion method. The results demonstrate that 1–2 have remarkable antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). 1 exhibit higher antibacterial properties against S. aurenu (MIC = 0.00095 μg/mL) and E. coil (MIC = 0.0019 μg/mL). In the same experimental conditions, the two complexes display more potent activity relative to standard antibiotics Kanamycin and Ampicillin.

Diorganotin（IV）与配体的反应（HL ¹  = 3-氨基吡啶-2-甲醛N（4）甲基硫代半碳酰胺，HL ²  = 3-氨基吡啶-2-甲醛N（4）-二甲基硫代半碳酮）得到两种化合物[PhSn（L ¹）Cl ₂ ]（1）和[（Ph）₂ Sn（L ²）Cl]（2）。这些化合物通过元素分析，红外光谱，紫外可见光谱和X射线晶体学进行表征。通过圆盘扩散法测定了配体和相应的复合物对不同病原菌的体外药物活性。结果表明1 –2对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）具有显着的抗菌活性。1对金黄色葡萄球菌（MIC = 0.00095μg / mL）和大肠杆菌（MIC = 0.0019μg / mL）表现出更高的抗菌性能。在相同的实验条件下，相对于标准抗生素卡那霉素和氨苄青霉素，两种复合物均显示出更强的活性。