Stan Falkow looked at the world with his eyes peering from the outer membrane of a gram-negative bacterium. It was a great vantage point from which to dream about the possible superpowers these organisms might have. He mused about these dreams with his trainees who sometimes found through rigorous scientific exploration that the superpowers really were there! Stan also realized that bacterial pathogenesis by definition was a two-way street, and that masterful understanding of bacterial virulence factors also required a masterful understanding of host cell processes against which the virulence factors were deployed. In my own scientific journey, I have sought to explore bacterial-host interactions that result in subtle alterations of the host's adaptive immune response. Here, as an example, I describe an interaction between Chlamydia trachomatis and host T cells that may contribute to the establishment of persistent infection.

中文翻译：

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进化良好的病原体。

Stan Falkow 用他的眼睛从革兰氏阴性细菌的外膜凝视着这个世界。这是梦想这些生物可能拥有的超级大国的绝佳有利位置。他与他的学员一起思考这些梦想，他们有时通过严格的科学探索发现超级大国真的存在！Stan 还意识到，从定义上讲，细菌发病机制是一条双向的道路，对细菌毒力因子的熟练理解还需要对毒力因子所针对的宿主细胞过程有熟练的理解。在我自己的科学之旅中，我试图探索导致宿主适应性免疫反应发生微妙变化的细菌-宿主相互作用。在这里，作为一个例子，