A search of the PubMed and Web of Science databases for articles on skin picking in PWS was undertaken identifying case studies; trials of specific treatments; and descriptions of when skin picking occurs, what sites are chosen, and what initiates and sustains this behaviour. Published papers have also considered how skin picking might link to the PWS genotype and whether it is best considered to be part of the repetitive and ritualistic behaviours characteristic of the syndrome. To answer specific questions raised as a result of the review additional analysis was undertaken using data from our earlier population-based study of PWS. We consider this behaviour of skin picking using the framework of the Research Domains Criteria that is cross diagnostic and focuses on the identification of specific neurobiological, psychological and cognitive processes. PWS illustrates the likely interplay between different processes that first initiate and then maintain such behaviour. Treatment development depends on better understanding these mechanisms and their relative contribution to the behaviour.

中文翻译：

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发展对Prader-Willi综合征患者的皮肤采摘的理解：结构化文献综述和对现有数据的重新分析。

在PubMed和Web of Science数据库中搜索了有关PWS中皮肤采摘的文章，以确定案例研究；具体治疗的试验；以及何时发生皮肤采摘，选择了哪些站点以及由什么发起和维持这种行为的描述。发表的论文还考虑了皮肤采摘如何与PWS基因型相关联，以及是否最好将其视为该综合征的重复性和礼节性行为的一部分。为了回答审查后提出的具体问题，使用了我们先前基于人群的PWS研究的数据进行了进一步分析。我们使用交叉诊断的“研究领域标准”框架来考虑这种采摘皮肤的行为，该框架专注于鉴定特定的神经生物学，心理和认知过程。PWS说明了首先启动然后维护这种行为的不同进程之间可能存在的相互作用。治疗的发展取决于对这些机制及其对行为的相对贡献的更好理解。