Allantoin is a commodity molecule widely used in cosmetic and pharmaceutical industry for its moisturizing properties. Although allantoin is a naturally occurring compound, its extraction is not economically viable on the industrial scale. Its production relies on urea and glyoxylic acid as starting materials. Current methods need long reaction times and use additives that raise safety and environmental issues. This work presents a novel process toward allantoin that uses Design of Experiments (DoE) and flow chemistry techniques. Intensified continuous flow conditions enable the preparation of high purity allantoin with a productivity of isolated product of 4.65 g h⁻¹. The research of alternative and more environmental friendly additives for the preparation of allantoin emphasizes that glyoxylic acid itself (in slight excess) is an effective catalyst for the reaction, paving the way to the development of more sustainable synthetic processes.

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尿囊素是一种商品分子，由于其保湿特性而广泛用于化妆品和制药行业。尽管尿囊素是天然存在的化合物，但其提取在工业规模上在经济上不可行。其生产依赖于尿素和乙醛酸作为起始原料。当前的方法需要较长的反应时间，并使用会引起安全和环境问题的添加剂。这项工作提出了一种使用实验设计（DoE）和流化学技术的尿囊素新工艺。增强的连续流动条件能够制备高纯度的尿囊素，分离产物的产率为4.65 g h ^-1。制备尿囊素的替代品和更环保的添加剂的研究强调，乙醛酸本身（略有过量）是反应的有效催化剂，为开发更具可持续性的合成方法铺平了道路。

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