Hydrogen sulfide, nitric oxide, and carbon monoxide are endogenously produced gases that regulate various signaling pathways. The role of these transmitters is complex as constitutive production of these molecules may have anti-inflammatory, anti-microbial, and/or vasodilatory effects whereas induced production or formation of secondary metabolites may lead to cellular death. Given this fine line between friend and foe, therapeutic attenuation of these molecules' production has involved both inhibition of endogenous formation and therapeutic supplementation. All three gases have been implicated as regulators of critical aspects of neonatal physiology, and in turn, comorbidities including necrotizing enterocolitis, hypoxic ischemic encephalopathy, and pulmonary hypertension. In this review, we present current perspectives on these associations, highlight areas where insights remain sparse, and identify areas for potential for future investigations.

中文翻译：

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新生儿合并症和气体递质。

硫化氢，一氧化氮和一氧化碳是内源性产生的气体，可调节各种信号通路。这些递质的作用是复杂的，因为这些分子的组成性产生可能具有抗炎，抗微生物和/或血管扩张作用，而诱导产生或形成的次级代谢产物则可能导致细胞死亡。考虑到敌与敌之间的界线，这些分子产生的治疗性减弱涉及内源性形成的抑制和治疗性补充。所有这三种气体均被认为是新生儿生理学关键方面的调节者，进而引起合并症，包括坏死性小肠结肠炎，缺氧缺血性脑病和肺动脉高压。在这篇评论中，我们介绍了有关这些关联的最新观点，