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Effects of particulate matter gamma radiation on oxidative stress biomarkers in COPD patients.
Journal of Exposure Science and Environmental Epidemiology ( IF 4.5 ) Pub Date : 2020-02-03 , DOI: 10.1038/s41370-020-0204-8
Shaodan Huang 1 , Petros Koutrakis 1 , Stephanie T Grady 2, 3 , Carolina L Z Vieira 1 , Joel D Schwartz 1, 3, 4 , Brent A Coull 1, 5 , Jaime E Hart 1, 3 , Francine Laden 1, 3, 4 , Junfeng Jim Zhang 6 , Eric Garshick 3, 7
Affiliation  

Inhalation of particulate matter (PM) radioactivity is an important pathway of ionizing radiation exposure. We investigated the associations between short-term exposures to PM gamma radioactivity with oxidative stress in COPD patients. Urinary concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) of 81 COPD patients from Eastern Massachusetts were measured 1-4 times during 2012-2014. Daily ambient and indoor PM gamma activities (gamma-3 through gamma-9) were calculated based on EPA RadNet data and indoor-outdoor infiltration ratios. Linear mixed-effects models were used to examine the associations between biomarkers with PM gamma activities for moving averages from urine collection day to 7 days before. Our results indicate that ambient and indoor PM gamma activities were positively associated with 8-OHdG, with stronger effects for exposure windows closer to urine collection day. For per interquartile range increase in indoor PM gamma activities averaged over urine collection day and 1 day before, 8-OHdG increased from 3.41% (95% CI: -0.88, 7.88) to 8.87% (95% CI: 2.98, 15.1), adjusted for indoor black carbon. For MDA, the timing of greatest effects across the exposure week varied but was nearly all positive. These findings provide insight into the toxigenic properties associated with PM radioactivity and suggest that these exposures promote systemic oxidative stress.

中文翻译:

颗粒物伽马辐射对 COPD 患者氧化应激生物标志物的影响。

吸入颗粒物 (PM) 放射性是电离辐射暴露的重要途径。我们调查了 COPD 患者短期暴露于 PM γ 放射性与氧化应激之间的关联。在 2012-2014 年期间,对来自马萨诸塞州东部的 81 名 COPD 患者的尿液 8-羟基-2'-脱氧鸟苷 (8-OHdG) 和丙二醛 (MDA) 浓度进行了 1-4 次测量。根据 EPA RadNet 数据和室内外渗透率计算每日环境和室内 PM 伽玛活动(gamma-3 到 gamma-9)。线性混合效应模型用于检查生物标志物与 PM 伽马活动之间的关联,用于从尿液收集日到 7 天前的移动平均值。我们的结果表明,环境和室内 PM 伽马活动与 8-OHdG 呈正相关,对接近尿液收集日的暴露窗口有更强的影响。对于尿液收集日和前 1 天室内 PM γ 活动的每四分位间距增加,8-OHdG 从 3.41%(95% CI:-0.88,7.88)增加到 8.87%(95% CI:2.98,15.1),针对室内炭黑进行调整。对于 MDA,在暴露周内产生最大影响的时间各不相同,但几乎都是积极的。这些发现提供了对与 PM 放射性相关的产毒特性的深入了解,并表明这些暴露会促进全身氧化应激。针对室内炭黑进行调整。对于 MDA,在暴露周内产生最大影响的时间各不相同,但几乎都是积极的。这些发现提供了对与 PM 放射性相关的产毒特性的深入了解,并表明这些暴露会促进全身氧化应激。针对室内炭黑进行调整。对于 MDA,在暴露周内产生最大影响的时间各不相同,但几乎都是积极的。这些发现提供了对与 PM 放射性相关的产毒特性的深入了解,并表明这些暴露会促进全身氧化应激。
更新日期:2020-02-03
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