We are approaching the 100th anniversary of Otto Warburg’s first description of the metabolic phenotype bearing his name—a propensity for tumours to metabolize glucose anaerobically rather than aerobically, even when oxygen is available. Generations of scientists have studied the Warburg effect, yet misconceptions persist about its causes and relationship to oxidative metabolism in the mitochondria. Here, we review the definition of the Warburg effect and discuss its place within a modern understanding of cancer biology.

中文翻译：

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我们需要谈论沃堡效应。

我们正接近奥托·沃堡（Otto Warburg）首次以他的名字描述代谢表型的100周年纪念—即使有氧气，肿瘤也倾向于厌氧而不是需氧代谢葡萄糖。几代科学家已经研究了Warburg效应，但对于线粒体中其氧化代谢的原因及其与氧化代谢的关系的误解仍然存在。在这里，我们回顾了Warburg效应的定义，并讨论了其在现代癌症生物学理解中的地位。