Two-dimensional (2D) nanomaterials have raised significant interest in not only energy and environmental fields but also biomedical areas. Among these materials, one type that has many interesting properties and possesses numerous exciting applications is graphene oxide (GO)-based 2D materials. However, their poor stability in aqueous solutions and weak bioactivities limit their use in biomedical applications, especially antimicrobial fields. In this study, GO was functionalized with hydrophilic polymers and used as a vector for silver nanoparticles (Ag NPs) and sulfadiazine (SD). The stability of the material in aqueous solutions was greatly improved. The antibacterial activity of the novel hybrid antibacterial system (HAS) was enhanced by over 3 times compared to that of the system lacking SD. The antibacterial performance of the HAS was due to the triple synergy: bacterial capping, puncture, and inhibition. This study provides new insights into the design and fabrication of surface-modified GO and carbon materials and their 2D hybrid multifunctional materials for advanced applications including biomedical and especially antibacterial applications, broadening the design and application scope of carbon and 2D materials.

二维（2D）纳米材料不仅在能源和环境领域，而且在生物医学领域都引起了人们的极大兴趣。在这些材料中，一种具有许多有趣的特性并具有许多令人兴奋的应用的类型是基于氧化石墨烯（GO）的2D材料。但是，它们在水溶液中的差的稳定性和弱的生物活性限制了它们在生物医学应用中的应用，尤其是在抗菌领域。在这项研究中，GO被亲水性聚合物官能化，并用作银纳米颗粒（Ag NPs）和磺胺嘧啶（SD）的载体。该材料在水溶液中的稳定性大大提高。与没有SD的系统相比，新型混合抗菌系统（HAS）的抗菌活性提高了3倍以上。HAS的抗菌性能归因于三重协同作用：细菌加帽，穿刺和抑制。这项研究为表面改性的GO和碳材料及其2D混合多功能材料的设计和制造提供了新的见解，这些先进的应用包括生物医学尤其是抗菌应用，拓宽了碳和2D材料的设计和应用范围。