Abstract

Electrospun membranes containing curcumin were prepared from poly(L-co-D,L-lactic) acid and polyvinylpyrrolidone. The effect of curcumin concentration on the solution viscosity and the morphology of fiber was studied. Curcumin solubility in aqueous solutions was enhanced by the formation of curcumin/polyvinylpyrrolidone water-soluble complex. Curcumin physico-chemical and therapeutic properties within the membranes were preserved upon UV-Vis light irradiation, as a part of the membranes sterilization. The biomaterials showed antibacterial activity against pathogenic microorganisms such as Staphylococcus aureus and Candida albicans. In-vitro experiments against HeLa and Graffi tumor cells and white blood cells (peritoneal macrophages and spleen lymphocytes) revealed potential biomedical application of the membranes.

中文翻译：

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姜黄素-PVP负载电纺膜具有抗细菌和抗肿瘤活性

摘要

由聚（L-co-D，L-乳酸）酸和聚乙烯吡咯烷酮制备含有姜黄素的电纺膜。研究了姜黄素浓度对溶液粘度和纤维形态的影响。姜黄素/聚乙烯吡咯烷酮水溶性复合物的形成增强了姜黄素在水溶液中的溶解度。膜中姜黄素的理化性质和治疗特性在UV-Vis光照射下得以保留，作为膜灭菌的一部分。该生物材料对诸如金黄色葡萄球菌和白色念珠菌的病原微生物具有抗菌活性。 针对HeLa和Graffi肿瘤细胞和白细胞（腹膜巨噬细胞和脾淋巴细胞）的体外实验显示了膜的潜在生物医学应用。