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100th Anniversary of Macromolecular Science Viewpoint: Opportunities in the Physics of Sequence-Defined Polymers
ACS Macro Letters ( IF 5.8 ) Pub Date : 2020-01-30 , DOI: 10.1021/acsmacrolett.0c00002
Sarah L Perry 1 , Charles E Sing 2
Affiliation  

Polymer science has been driven by ever-increasing molecular complexity, as polymer synthesis expands an already-vast palette of chemical and architectural parameter space. Copolymers represent a key example, where simple homopolymers have given rise to random, alternating, gradient, and block copolymers. Polymer physics has provided the insight needed to explore this monomer sequence parameter space. The future of polymer science, however, must contend with further increases in monomer precision, as this class of macromolecules moves ever closer to the sequence-monodisperse polymers that are the workhorses of biology. The advent of sequence-defined polymers gives rise to opportunities for material design, with increasing levels of chemical information being incorporated into long-chain molecules; however, this also raises questions that polymer physics must address. What properties uniquely emerge from sequence-definition? Is this circumstance-dependent? How do we define and think about sequence dispersity? How do we think about a hierarchy of sequence effects? Are more sophisticated characterization methods, as well as theoretical and computational tools, needed to understand this class of macromolecules? The answers to these questions touch on many difficult scientific challenges, setting the stage for a rich future for sequence-defined polymers in polymer physics.

中文翻译:

高分子科学100周年视点:序列定义聚合物物理学中的机遇

聚合物科学一直受到不断增加的分子复杂性的推动,因为聚合物合成扩展了已经很广阔的化学和结构参数空间。共聚物是一个关键的例子,简单的均聚物产生了无规、交替、梯度和嵌段共聚物。聚合物物理学提供了探索这种单体序列参数空间所需的洞察力。然而,聚合物科学的未来必须应对单体精度的进一步提高,因为这类大分子越来越接近作为生物学主力的序列单分散聚合物。序列定义聚合物的出现为材料设计带来了机会,越来越多的化学信息被整合到长链分子中;然而,这也提出了聚合物物理学必须解决的问题。序列定义有哪些独特的特性?这取决于环境吗?我们如何定义和思考序列分散性?我们如何看待序列效应的层次结构?理解这类大分子是否需要更复杂的表征方法以及理论和计算工具?这些问题的答案涉及许多困难的科学挑战,为聚合物物理学中序列定义聚合物的美好未来奠定了基础。以及理解这类大分子所需的理论和计算工具?这些问题的答案涉及许多困难的科学挑战,为聚合物物理学中序列定义聚合物的美好未来奠定了基础。以及理解这类大分子所需的理论和计算工具?这些问题的答案涉及许多困难的科学挑战,为聚合物物理学中序列定义聚合物的美好未来奠定了基础。
更新日期:2020-01-31
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