AIM This study aimed to assess the extent to which the association between recent alcohol consumption and risk of non-traffic injury varies according to location at the time of the injury. DESIGN Case-crossover design. Setting and participants 15,625 injury patients from 49 emergency departments (EDs) in 22 countries. MEASUREMENTS Recent alcohol consumption and location at the time of the injury were assessed for when the injury occurred and for the same time 1 week prior to this. The confounding and interactive effects of location were examined by estimating the adjusted odds ratio (OR) of injury from alcohol consumption adjusting for location and then by examining the alcohol consumption-location interaction. FINDINGS There were significant interactive effects of location and alcohol consumption on injury risk. For example, the ORs for volume 0.1-3.0 drinks and street/public place each were 3.0 and 14.2, respectively, whereas the OR for their joint effect was 44.1, suggesting a positive additive interaction (relative excess risk due to interaction [RERI]=27.9, p<0.05) and zero multiplicative interaction (OR=1.0, p=0.895). The interactions of alcohol consumption with drinking establishment location, workplace and other locations were mostly additive and negative on the multiplicative scale (e.g. for interaction between volume 0.1-3.0 drinks and drinking establishment location: RERI=1.2, p=0.529; multiplicative interaction OR=0.54, p<0.05). CONCLUSIONS Location appears to influence the relationship between alcohol consumption and risk of injury. The association between alcohol consumption and injury appears to be greater in locations such as streets and public places compared with private residences.

中文翻译：

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位置、饮酒与非交通伤害的交互作用

目的 本研究旨在评估近期饮酒与非交通伤害风险之间的关联程度因受伤时所处的位置而异。设计案例交叉设计。设置和参与者来自 22 个国家的 49 个急诊科 (ED) 的 15,625 名受伤患者。测量 近期饮酒量和受伤时的位置被评估为受伤发生的时间和在此之前 1 周的同一时间。位置的混杂和交互作用通过估计酒精消耗调整位置的调整优势比（OR），然后通过检查酒精消耗-位置交互作用来检查。发现 地点和饮酒对伤害风险有显着的交互作用。例如，卷 0 的 OR。1-3.0 饮料和街道/公共场所分别为 3.0 和 14.2，而其联合效应的 OR 为 44.1，表明存在正相加相互作用（相互作用导致的相对超额风险 [RERI]=27.9，p<0.05）和零乘性相互作用（OR=1.0，p=0.895）。酒精消费与饮酒场所位置、工作场所和其他位置的交互作用在乘法尺度上大多为加性和负值（例如，0.1-3.0 量饮料与饮酒场所位置之间的交互作用：RERI=1.2，p=0.529；乘法交互作用 OR= 0.54，p<0.05)。结论 位置似乎影响饮酒和受伤风险之间的关系。