The m⁶A‐RNA modification is a dynamic and reversible process, which has emerged as a new RNA code for the regulation of gene expression. The functional network of methyltransferases (writers), demethylases (erasers), and binding proteins (readers) modulate the level of m⁶A modification. Dysfunction of RNA methylation has been associated with various fundamental biological processes and human diseases. Herein, we briefly introduce an understanding‐enabled manipulation on m⁶A‐RNA modification with an emphasis on the use of small‐molecule intervention.

中文翻译：

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RNA甲基化m6A：新法规和药物靶标？

m ⁶ A‐RNA修饰是一个动态且可逆的过程，已成为调节基因表达的新RNA编码。甲基转移酶（编写程序），脱甲基酶（擦除程序）和结合蛋白（读取程序）的功能网络调节m ⁶ A修饰的水平。RNA甲基化功能障碍与各种基本生物学过程和人类疾病有关。在此，我们简要介绍对m ⁶ A-RNA修饰的理解理解操作，重点是小分子干预的使用。