Acute pancreatitis (AP) is an inflammatory disease of the pancreas that causes significant morbidity and mortality worldwide. Unfortunately, there is no specific treatment available to date. Several studies have previously shown that inhibitors of the PI3K/Akt axis downregulate the degree of inflammation in animal models of AP. However, studies on in vivo side-effects of such inhibitors are still lacking. In a recent issue of The Journal of Pathology, Chen, Malagola et al investigated if inhibition of Akt signaling plays a negative role in the regenerative phase of AP. They showed that treating AP mice with an Akt inhibitor (MK2206) impaired acinar regeneration and increased the development of acinar-to-ductal metaplasia. This is the first study to highlight the negative impact of an Akt inhibitor on cellular regeneration while simultaneously inhibiting inflammation in AP. The authors also suggested combining Akt activators to recover pancreatic regeneration. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

中文翻译：

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Akt1信号在急性胰腺炎进展中的关键作用†。

急性胰腺炎（AP）是一种胰腺炎性疾病，在全世界范围内引起大量发病和死亡。不幸的是，迄今为止尚无特定的治疗方法。先前的一些研究表明，PI3K / Akt轴抑制剂在AP动物模型中下调了炎症程度。但是，仍然缺乏关于这种抑制剂的体内副作用的研究。Chen，Malagola等人在最近出版的《病理学杂志》中研究了Akt信号转导的抑制在AP的再生阶段是否起负作用。他们显示，用Akt抑制剂（MK2206）治疗AP小鼠会损害腺泡再生，并增加腺泡到导管化生的发展。这是第一项强调Akt抑制剂对细胞再生同时抑制AP炎症的负面影响的研究。作者还建议结合使用Akt激活剂来恢复胰腺再生。©2020作者。John Wiley＆Sons Ltd代表大不列颠及爱尔兰病理学会出版的《病理学杂志》。