Selenium (Se) is an essential trace element that functions in the form of the 21st amino acid, selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with pathological conditions in humans and animals, where incorporation of Sec into selenoproteins is reduced along with their expression and catalytic activity. Supplementation of Se-deficient population with Se has shown health benefits suggesting the importance of Se in physiology. An interesting paradigm to explain, in part, the health benefits of Se stems from the observations that selenoprotein-dependent modulation of inflammation and efficient resolution of inflammation relies on mechanisms involving a group of bioactive lipid mediators, prostanoids, which orchestrate a concerted action toward maintenance and restoration of homeostatic immune responses. Such an effect involves the interaction of various immune cells with these lipid mediators where cellular redox gatekeeper functions of selenoproteins further aid in not only dampening inflammation, but also initiating an effective and active resolution process. Here we have summarized the current literature on the multifaceted roles of Se/selenoproteins in the regulation of these bioactive lipid mediators and their immunomodulatory effects.

硒（Se）是必需的微量元素，在定义的一组蛋白质中以第21个氨基酸硒半胱氨酸（Sec）的形式起作用。硒缺乏症与人类和动物的病理状况有关，在这种状况下，Sec掺入硒蛋白的表达，催化活性会降低。向硒缺乏的人群补充硒已显示出健康益处，表明硒在生理学中的重要性。一个有趣的范例，可以部分解释Se的健康益处，这一发现源于以下观察结果：硒蛋白依赖性炎症调节和炎症有效消除依赖于涉及一组生物活性脂质介质，类前列腺素的机制，这些机制协调一致地致力于维持生命。和恢复稳态免疫反应。这种作用涉及各种免疫细胞与这些脂质介体的相互作用，其中硒蛋白的细胞氧化还原关守功能进一步帮助不仅减轻炎症，而且还启动了有效而积极的解决过程。在这里，我们总结了有关硒/硒蛋白在这些生物活性脂质介体的调节及其免疫调节作用中的多方面作用的最新文献。