Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.

中文翻译：

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针对冠状病毒的抑制剂的最新发现和开发。

人冠状病毒（CoV）是具有正反义单链RNA基因组的包膜病毒。目前，已报告了六种人类冠状病毒，包括人类冠状病毒229E（HCoV-229E），OC43（HCoV-OC43），NL63（HCoV-NL63），HKU1（HCoV-HKU1），严重急性呼吸综合征（SARS）冠状病毒（SARS- CoV）和中东呼吸综合征（MERS）冠状病毒（MERS-CoV）。它们引起人类中度到重度的呼吸道和肠道感染。在这篇综述中，我们重点研究针对CoV生命周期不同阶段的小分子抗人类冠状病毒疗法的研究和开发的最新进展。